We are analyzing https://link.springer.com/article/10.1007/s10555-024-10171-0.

Title:
Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics | Cancer and Metastasis Reviews
Description:
Recent advances have brought forth the complex interplay between tumor cell plasticity and its consequential impact on drug resistance and tumor recurrence, both of which are critical determinants of neoplastic progression and therapeutic efficacy. Various forms of tumor cell plasticity, instrumental in facilitating neoplastic cells to develop drug resistance, include epithelial-mesenchymal transition (EMT) alternatively termed epithelial-mesenchymal plasticity, the acquisition of cancer stem cell (CSC) attributes, and transdifferentiation into diverse cell lineages. Nuclear receptors (NRs) are a superfamily of transcription factors (TFs) that play an essential role in regulating a multitude of cellular processes, including cell proliferation, differentiation, and apoptosis. NRs have been implicated to play a critical role in modulating gene expression associated with tumor cell plasticity and drug resistance. This review aims to provide a comprehensive overview of the current understanding of how NRs regulate these key aspects of cancer biology. We discuss the diverse mechanisms through which NRs influence tumor cell plasticity, including EMT, stemness, and metastasis. Further, we explore the intricate relationship between NRs and drug resistance, highlighting the impact of NR signaling on chemotherapy, radiotherapy and targeted therapies. We also discuss the emerging therapeutic strategies targeting NRs to overcome tumor cell plasticity and drug resistance. This review also provides valuable insights into the current clinical trials that involve agonists or antagonists of NRs modulating various aspects of tumor cell plasticity, thereby delineating the potential of NRs as therapeutic targets for improved cancer treatment outcomes. Graphical Abstract
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, central, cell, receptor, cells, stem, journal, breast, nuclear, receptors, molecular, signaling, resistance, httpsdoiorgs, nature, clinical, research, biology, wang, expression, tumor, transition, therapy, plasticity, prostate, reviews, vitamin, oncology, trial, epithelialmesenchymal, human, chen, drug, liu, acid, orphan, zhang, estrogen, retinoic, httpsdoiorg, patients, metastasis, androgen, emt, gene,

Topics {✒️}

bt/556/ne/u-excel/2016 grant awarded lnctcfl5-2-ybx1-sox2 signaling axis mir-18a-downregulated rora inhibits phosphatidylinositol 3-kinase/akt-mediated activation e-cadherin invasion-suppressor gene signal-transduction-pathway-specific desensitization /mir-520f-3p/sox9 signaling beta-catenin/lef-1 signaling pathway month download article/chapter restored tgf-β-smad4 signaling targeting hsa-mir-485-5p/rxralpha t-cell receptor-mediated apoptosis estrogen-related receptor alpha mitogen-activated protein kinase shrna-mediated pparalpha knockdown twist1-induced epithelial-mesenchymal transition pi3k/akt signaling pathways retinoic acid-induced differentiation cutaneous t-cell lymphoma phospholipase a2-dependent manner antagonizing p53-mediated apoptosis egfr/her2 signaling pathway e-cadherin germline mutations retinoic-acid-induced reprogramming repressing e-cadherin expression hormone-sensitive prostate cancer niclosamide induces mir-148a e-cadherin gene expression retinoid-related orphan receptors wnt/beta-catenin pathway inhibiting beta-catenin signaling tetrachlorodibenzo-p-dioxin bpa triple-negative breast cancer slug regulates e-cadherin androgen receptor-targeted therapy wnt/β-catenin signaling induced epithelial-mesenchymal transition estrogen receptor alpha estrogen receptor-alpha therapy-induced lineage plasticity her2-negative breast cancer tumor-targeted nanoparticles deliver kdm6b/jmjd3 histone demethylase open-label pilot study thyrotropin-beta promoter activity include epithelial-mesenchymal transition oral cancer-emerging players targeted therapy-induced resistance common tumor-suppressor phenotype emt-inducing transcription factors

Questions {❓}

Targeting Wnt signaling: Can we safely eradicate cancer stem cells?
Targeting minimal residual disease: A path to cure?
The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics
         description:Recent advances have brought forth the complex interplay between tumor cell plasticity and its consequential impact on drug resistance and tumor recurrence, both of which are critical determinants of neoplastic progression and therapeutic efficacy. Various forms of tumor cell plasticity, instrumental in facilitating neoplastic cells to develop drug resistance, include epithelial-mesenchymal transition (EMT) alternatively termed epithelial-mesenchymal plasticity, the acquisition of cancer stem cell (CSC) attributes, and transdifferentiation into diverse cell lineages. Nuclear receptors (NRs) are a superfamily of transcription factors (TFs) that play an essential role in regulating a multitude of cellular processes, including cell proliferation, differentiation, and apoptosis. NRs have been implicated to play a critical role in modulating gene expression associated with tumor cell plasticity and drug resistance. This review aims to provide a comprehensive overview of the current understanding of how NRs regulate these key aspects of cancer biology. We discuss the diverse mechanisms through which NRs influence tumor cell plasticity, including EMT, stemness, and metastasis. Further, we explore the intricate relationship between NRs and drug resistance, highlighting the impact of NR signaling on chemotherapy, radiotherapy and targeted therapies. We also discuss the emerging therapeutic strategies targeting NRs to overcome tumor cell plasticity and drug resistance. This review also provides valuable insights into the current clinical trials that involve agonists or antagonists of NRs modulating various aspects of tumor cell plasticity, thereby delineating the potential of NRs as therapeutic targets for improved cancer treatment outcomes.
         datePublished:2024-03-22T00:00:00Z
         dateModified:2024-03-22T00:00:00Z
         pageStart:321
         pageEnd:362
         sameAs:https://doi.org/10.1007/s10555-024-10171-0
         keywords:
            Cancer
            Cancer cell plasticity
            Cancer stem cells
            EMT
            Chemoresistance
            Nuclear receptors
            Cancer therapy
            Cancer Research
            Oncology
            Biomedicine
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-024-10171-0/MediaObjects/10555_2024_10171_Figa_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-024-10171-0/MediaObjects/10555_2024_10171_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-024-10171-0/MediaObjects/10555_2024_10171_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-024-10171-0/MediaObjects/10555_2024_10171_Fig3_HTML.png
         isPartOf:
            name:Cancer and Metastasis Reviews
            issn:
               1573-7233
               0167-7659
            volumeNumber:43
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Bandari BharathwajChetty
               affiliation:
                     name:Indian Institute of Technology Guwahati (IITG)
                     address:
                        name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anjana Sajeev
               affiliation:
                     name:Indian Institute of Technology Guwahati (IITG)
                     address:
                        name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ravichandran Vishwa
               affiliation:
                     name:Indian Institute of Technology Guwahati (IITG)
                     address:
                        name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Babu Santha Aswani
               affiliation:
                     name:Indian Institute of Technology Guwahati (IITG)
                     address:
                        name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mohammed S. Alqahtani
               affiliation:
                     name:King Khalid University
                     address:
                        name:Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mohamed Abbas
               affiliation:
                     name:King Khalid University
                     address:
                        name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ajaikumar B. Kunnumakkara
               affiliation:
                     name:Indian Institute of Technology Guwahati (IITG)
                     address:
                        name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics
      description:Recent advances have brought forth the complex interplay between tumor cell plasticity and its consequential impact on drug resistance and tumor recurrence, both of which are critical determinants of neoplastic progression and therapeutic efficacy. Various forms of tumor cell plasticity, instrumental in facilitating neoplastic cells to develop drug resistance, include epithelial-mesenchymal transition (EMT) alternatively termed epithelial-mesenchymal plasticity, the acquisition of cancer stem cell (CSC) attributes, and transdifferentiation into diverse cell lineages. Nuclear receptors (NRs) are a superfamily of transcription factors (TFs) that play an essential role in regulating a multitude of cellular processes, including cell proliferation, differentiation, and apoptosis. NRs have been implicated to play a critical role in modulating gene expression associated with tumor cell plasticity and drug resistance. This review aims to provide a comprehensive overview of the current understanding of how NRs regulate these key aspects of cancer biology. We discuss the diverse mechanisms through which NRs influence tumor cell plasticity, including EMT, stemness, and metastasis. Further, we explore the intricate relationship between NRs and drug resistance, highlighting the impact of NR signaling on chemotherapy, radiotherapy and targeted therapies. We also discuss the emerging therapeutic strategies targeting NRs to overcome tumor cell plasticity and drug resistance. This review also provides valuable insights into the current clinical trials that involve agonists or antagonists of NRs modulating various aspects of tumor cell plasticity, thereby delineating the potential of NRs as therapeutic targets for improved cancer treatment outcomes.
      datePublished:2024-03-22T00:00:00Z
      dateModified:2024-03-22T00:00:00Z
      pageStart:321
      pageEnd:362
      sameAs:https://doi.org/10.1007/s10555-024-10171-0
      keywords:
         Cancer
         Cancer cell plasticity
         Cancer stem cells
         EMT
         Chemoresistance
         Nuclear receptors
         Cancer therapy
         Cancer Research
         Oncology
         Biomedicine
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-024-10171-0/MediaObjects/10555_2024_10171_Figa_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-024-10171-0/MediaObjects/10555_2024_10171_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-024-10171-0/MediaObjects/10555_2024_10171_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10555-024-10171-0/MediaObjects/10555_2024_10171_Fig3_HTML.png
      isPartOf:
         name:Cancer and Metastasis Reviews
         issn:
            1573-7233
            0167-7659
         volumeNumber:43
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Bandari BharathwajChetty
            affiliation:
                  name:Indian Institute of Technology Guwahati (IITG)
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anjana Sajeev
            affiliation:
                  name:Indian Institute of Technology Guwahati (IITG)
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ravichandran Vishwa
            affiliation:
                  name:Indian Institute of Technology Guwahati (IITG)
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Babu Santha Aswani
            affiliation:
                  name:Indian Institute of Technology Guwahati (IITG)
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mohammed S. Alqahtani
            affiliation:
                  name:King Khalid University
                  address:
                     name:Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mohamed Abbas
            affiliation:
                  name:King Khalid University
                  address:
                     name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ajaikumar B. Kunnumakkara
            affiliation:
                  name:Indian Institute of Technology Guwahati (IITG)
                  address:
                     name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Cancer and Metastasis Reviews
      issn:
         1573-7233
         0167-7659
      volumeNumber:43
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Indian Institute of Technology Guwahati (IITG)
      address:
         name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
         type:PostalAddress
      name:Indian Institute of Technology Guwahati (IITG)
      address:
         name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
         type:PostalAddress
      name:Indian Institute of Technology Guwahati (IITG)
      address:
         name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
         type:PostalAddress
      name:Indian Institute of Technology Guwahati (IITG)
      address:
         name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
         type:PostalAddress
      name:King Khalid University
      address:
         name:Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
      name:King Khalid University
      address:
         name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
         type:PostalAddress
      name:Indian Institute of Technology Guwahati (IITG)
      address:
         name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Bandari BharathwajChetty
      affiliation:
            name:Indian Institute of Technology Guwahati (IITG)
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
               type:PostalAddress
            type:Organization
      name:Anjana Sajeev
      affiliation:
            name:Indian Institute of Technology Guwahati (IITG)
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
               type:PostalAddress
            type:Organization
      name:Ravichandran Vishwa
      affiliation:
            name:Indian Institute of Technology Guwahati (IITG)
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
               type:PostalAddress
            type:Organization
      name:Babu Santha Aswani
      affiliation:
            name:Indian Institute of Technology Guwahati (IITG)
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
               type:PostalAddress
            type:Organization
      name:Mohammed S. Alqahtani
      affiliation:
            name:King Khalid University
            address:
               name:Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Mohamed Abbas
      affiliation:
            name:King Khalid University
            address:
               name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
               type:PostalAddress
            type:Organization
      name:Ajaikumar B. Kunnumakkara
      affiliation:
            name:Indian Institute of Technology Guwahati (IITG)
            address:
               name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
      name:Radiological Sciences Department, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia
      name:Electrical Engineering Department, College of Engineering, King Khalid University, Abha, Saudi Arabia
      name:Cancer Biology Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati (IITG), Guwahati, India
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(1318)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

6.19s.

LINK . SPRINGER . COM {}