
NCBI . NLM . NIH . GOV {
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Title[redir]:
Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin - PMC
Description:
All-trans retinoic acid (ATRA) and retinol significantly reduced ALDH1+ve cell subsets. Co-treatment of ATRA or retinol with cisplatin significantly inhibited NSCLC cell survival. Retinoic acid pathway inhibition induced apoptosis of chemo-resistant ...
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Keywords {๐}
cells, cell, doi, cancer, cisplatin, atra, pubmed, google, scholar, acid, treatment, nsclc, stem, retinoic, cisr, aldhve, expression, significantly, retinol, aldh, resistant, lung, pmc, lines, article, free, skmes, combination, cisplatinresistant, relative, resistance, response, differentiation, fig, csc, increased, sublines, observed, tumour, concentrations, apoptosis, subpopulation, reduced, significant, effects, survival, pathway, similar, treated, wang,
Topics {โ๏ธ}
ccaat/enhancer-binding protein beta pmc beta search induce cisplatin-dna cross-links step rt-qpcr kit small-cell lung cancer aldh1-ve fractions isolated aldh1-ve cell fractions symmetric stem-cell divisions enhancing tumor-specific uptake prolonged progression-free survival aldh1+ve subpopulations derived dr parviz behnam-motlagh prevent cisplatin-induced enrichment aldh1+ve cell population drug-resistant lung cancer undergo epithelial-mesenchymal transition aldhhigh/cd44+ subpopulations isolated aldh1+ve csc population mediate anti-tumor efficacy cisplatin-resistant lung cancer aldh1+ve cell subset pi3k-akt signaling pathways cisplatin-induced cell death cancer stem cell-specific fresh treatment-free media cisplatin-resistant cell lines fluorescence-activated cell sorting cisr aldh1+ve subpopulation aldh1+ve csc subpopulation aldh1+ve subpopulation relative aldh1+ve csc subset resilient drug-surviving subpopulation chemo-resistant nsclc cells cisplatin-resistant nsclc sublines aldh1+ve subpopulations identified control/parental cell lines malignant pleural mesothelioma skmes-1 aldh1+ve cells cisplatin-resistant nsclc cells cisplatin-resistant nsclc subtypes retinol/retinoic acid axis lineage-specific gene loss cd133+ tumor-initiating cells 2โฏยตl annexin-v-fitc gonzalez-de la rosa cisplatin-resistant sublines examined tumour-initiating csc phenotype display key stem cisplatin-resistant nsclc based characterised aldh1+ve cells
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