
NCBI . NLM . NIH . GOV {
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Title[redir]:
The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights - PMC
Description:
The vitamin D receptor (VDR) is the single known regulatory mediator of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in higher vertebrates. It acts in the nucleus of vitamin D target cells to regulate the expression of genes whose products ...
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Keywords {🔍}
doi, google, scholar, pubmed, vitamin, vdr, receptor, pmc, free, article, gene, expression, cells, ohd, cell, binding, pike, sites, regulation, bone, human, hormone, genes, studies, biol, regulatory, differentiation, dihydroxyvitamin, tissues, dna, mol, mouse, response, biological, disease, transcriptional, elements, transcription, target, function, meyer, mechanisms, specific, distal, enhancer, nuclear, factors, mmp, chem, actions,
Topics {✒️}
c-jun n-terminal kinase extra-renal 25-hydroxyvitamin d3-1α-hydroxylase estrogen receptor/coactivator recognition cell type–specific fashion pseudovitamin d-deficiency rickets 25-dihydroxyvitamin d-resistant rickets postmenopausal mexican-american women pmc beta search tcf4/β-catenin cistromes creb-binding protein/p300 pmc copyright notice cell type–specific expression 1-α-hydroxylase gene maps promoter-localized control elements trans-acting regulatory factors antibody-based detection methods enhancer-mediated hormonal control 25-dihydroxyvitamin d3-resistant rickets cytochrome p450-mediated metabolism terminally differentiated osteocytes c-myc gene expression ligand-bound vdr localizes tissue-specific vdr deletion tissue-specific gene expression regulatory cis elements vdr-regulated –10-kb enhancer chip-seq studies revealed numerous genome-wide studies osteoblast-lineage cell differentiation long-range control dna-bound transcription factors receptor-mediated genomic actions runx2-bound enhancer located vdr-mediated transcriptional regulation runx2-regulated –30-kb enhancer 25-dihydroxyvitamin d3-responsive genes [google scholar] 97 hair follicle cycling fgf23/klotho endocrine pathways translation initiation site publisher site pdf future directions recent genome-wide studies crispr/cas9 approach curr opin pharmacol transcription factor family potential beneficial effects license information pmcid contributor information largely ligand dependent
Questions {❓}
- Hepatic actions of vitamin D receptor ligands: a sunshine option for chronic liver disease?
- Where is the vitamin D receptor?
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- Financial intake of https://scholar.google.com/scholar_lookup?journal=Arch%20Biochem%20Biophys&title=The%20hair%20cycle%20and%20Vitamin%20D%20receptor&author=MB%20Demay&volume=523&issue=1&publication_year=2012&pages=19-21&pmid=22008469&doi=10.1016/j.abb.2011.10.002&
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- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=J%20Bone%20Miner%20Res&title=The%20vitamin%20D%20receptor%20gene%20start%20codon%20polymorphism:%20a%20functional%20analysis%20of%20FokI%20variants&author=C%20Gross&author=AV%20Krishnan&author=PJ%20Malloy&author=TR%20Eccleshall&author=XY%20Zhao&volume=13&issue=11&publication_year=1998&pages=1691-1699&pmid=9797477&doi=10.1359/jbmr.1998.13.11.1691&?
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- How much does https://scholar.google.com/scholar_lookup?journal=J%20Steroid%20Biochem%20Mol%20Biol&title=Multiple%20potential%20clinical%20benefits%20for%201alpha,25-dihydroxyvitamin%20D3%20analogs%20in%20kidney%20transplant%20recipients&author=MD%20Griffin&author=R%20Kumar&volume=97&issue=1%E2%80%932&publication_year=2005&pages=213-218&pmid=16026980&doi=10.1016/j.jsbmb.2005.06.014& pull in?
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