Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
  10. Analytics And Tracking
  11. Libraries
  12. Hosting Providers
  13. CDN Services

We began analyzing https://link.springer.com/article/10.1007/s10620-010-1536-3, but it redirected us to https://link.springer.com/article/10.1007/s10620-010-1536-3. The analysis below is for the second page.

Title[redir]:
miR-137 Is Frequently Down-Regulated in Gastric Cancer and Is a Negative Regulator of Cdc42 | Digestive Diseases and Sciences
Description:
Introduction MicroRNAs (miRNAs) are a class of small (19–25 nucleotides) noncoding RNAs that regulate the expressions of a wide variety of genes, including some involved in cancer development. Some recent studies show that DNA methylation contributes to down-regulation of microRNA-137 (miR-137) during tumorigenesis. Whether down-regulation of miR-137 also exists in gastric cancer is unknown. Aim Our aim was to test the hypothesis that down-regulation of miR-137 also exists in gastric cancer. Methods Expression of levels of miR-137 were examined using real-time PCR on paired gastric cancer and adjacent non-cancerous tissues. The methylation status is detected by MSP. Results Results show that miR-137 is downregulated by hypermethylation of the promoter in gastric cancer tissues. Epigenetic silencing of miR-137 induced an up-regulation of its targets, Cdc42. Restoration of the miR-137 expression in gastric cancer cell lines downregulated the Cdc42 expression. Restoration of the miR-137 and inactivation of Cdc42 induce apoptosis and cell cycle G1 arrest in gastric cancer cells. Furthermore, the miR-137 expression was found to be inversely correlated with CDC42 expression in gastric caner. Conclusions miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42.

Matching Content Categories {šŸ“š}

  • Health & Fitness
  • Education
  • Telecommunications

Content Management System {šŸ“}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 9,135,289 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {šŸ’ø}

We're unsure if the website is profiting.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Doi.org might be making money, but it's not detectable how they're doing it.

Keywords {šŸ”}

cancer, article, cdc, gastric, pubmed, google, scholar, cas, chen, cell, expression, access, zhang, res, privacy, cookies, content, downregulated, micrornas, cells, information, publish, search, methylation, downregulation, microrna, epigenetic, open, biol, zhengzhou, data, log, journal, research, frequently, negative, regulator, january, qingjiang, xiaobing, mingzhi, small, dna, hypermethylation, targets, lines, tumor, discover, control, liu,

Topics {āœ’ļø}

suxia luoĀ &Ā xinguang cao month download article/chapter raf-mek-erk cascade article digestive diseases tumor-suppressive micrornas silenced related subjects full article pdf dna methylation contributes gastric cancer cells melanoma cell lines paired gastric cancer privacy choices/manage cookies gastric cancer tissues internal medicine-oncology squamous cell carcinoma nat rev cancer mouse reveals delayed mol biol cell mol cell biol henan cancer hospital colorectal cancer cells glioblastoma multiforme cells affiliated cancer hospital european economic area recent studies show real-time pcr body mass index cd11b integrin signaling electronic supplementary material demethylation agent dac promotes cell death clin cancer res conditions privacy policy gastric cancer cdc42-interacting protein-4 noncoding rnas check access instant access microrna-137 promoter methylation dna hypermethylation accepting optional cookies cdc42 induce apoptosis article chen microrna-137 targets microphthalmia medicine-oncology article log author information authors bmc med western blot analysis journal finder publish

Schema {šŸ—ŗļø}

WebPage:
      mainEntity:
         headline:miR-137 Is Frequently Down-Regulated in Gastric Cancer and Is a Negative Regulator of Cdc42
         description:MicroRNAs (miRNAs) are a class of small (19–25 nucleotides) noncoding RNAs that regulate the expressions of a wide variety of genes, including some involved in cancer development. Some recent studies show that DNA methylation contributes to down-regulation of microRNA-137 (miR-137) during tumorigenesis. Whether down-regulation of miR-137 also exists in gastric cancer is unknown. Our aim was to test the hypothesis that down-regulation of miR-137 also exists in gastric cancer. Expression of levels of miR-137 were examined using real-time PCR on paired gastric cancer and adjacent non-cancerous tissues. The methylation status is detected by MSP. Results show that miR-137 is downregulated by hypermethylation of the promoter in gastric cancer tissues. Epigenetic silencing of miR-137 induced an up-regulation of its targets, Cdc42. Restoration of the miR-137 expression in gastric cancer cell lines downregulated the Cdc42 expression. Restoration of the miR-137 and inactivation of Cdc42 induce apoptosis and cell cycle G1 arrest in gastric cancer cells. Furthermore, the miR-137 expression was found to be inversely correlated with CDC42 expression in gastric caner. miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42.
         datePublished:2011-01-08T00:00:00Z
         dateModified:2011-01-08T00:00:00Z
         pageStart:2009
         pageEnd:2016
         sameAs:https://doi.org/10.1007/s10620-010-1536-3
         keywords:
            miR-137
            Gastric cancer
            Hypermethylation
            Cdc42
            Gastroenterology
            Hepatology
            Oncology
            Transplant Surgery
            Biochemistry
            general
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig5_HTML.gif
         isPartOf:
            name:Digestive Diseases and Sciences
            issn:
               1573-2568
               0163-2116
            volumeNumber:56
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Qingjiang Chen
               affiliation:
                     name:Zhengzhou University
                     address:
                        name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaobing Chen
               affiliation:
                     name:The Affiliated Cancer Hospital of Zhengzhou University
                     address:
                        name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mingzhi Zhang
               affiliation:
                     name:Zhengzhou University
                     address:
                        name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Qingxia Fan
               affiliation:
                     name:Zhengzhou University
                     address:
                        name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Suxia Luo
               affiliation:
                     name:The Affiliated Cancer Hospital of Zhengzhou University
                     address:
                        name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xinguang Cao
               affiliation:
                     name:The Affiliated Cancer Hospital of Zhengzhou University
                     address:
                        name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:miR-137 Is Frequently Down-Regulated in Gastric Cancer and Is a Negative Regulator of Cdc42
      description:MicroRNAs (miRNAs) are a class of small (19–25 nucleotides) noncoding RNAs that regulate the expressions of a wide variety of genes, including some involved in cancer development. Some recent studies show that DNA methylation contributes to down-regulation of microRNA-137 (miR-137) during tumorigenesis. Whether down-regulation of miR-137 also exists in gastric cancer is unknown. Our aim was to test the hypothesis that down-regulation of miR-137 also exists in gastric cancer. Expression of levels of miR-137 were examined using real-time PCR on paired gastric cancer and adjacent non-cancerous tissues. The methylation status is detected by MSP. Results show that miR-137 is downregulated by hypermethylation of the promoter in gastric cancer tissues. Epigenetic silencing of miR-137 induced an up-regulation of its targets, Cdc42. Restoration of the miR-137 expression in gastric cancer cell lines downregulated the Cdc42 expression. Restoration of the miR-137 and inactivation of Cdc42 induce apoptosis and cell cycle G1 arrest in gastric cancer cells. Furthermore, the miR-137 expression was found to be inversely correlated with CDC42 expression in gastric caner. miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42.
      datePublished:2011-01-08T00:00:00Z
      dateModified:2011-01-08T00:00:00Z
      pageStart:2009
      pageEnd:2016
      sameAs:https://doi.org/10.1007/s10620-010-1536-3
      keywords:
         miR-137
         Gastric cancer
         Hypermethylation
         Cdc42
         Gastroenterology
         Hepatology
         Oncology
         Transplant Surgery
         Biochemistry
         general
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10620-010-1536-3/MediaObjects/10620_2010_1536_Fig5_HTML.gif
      isPartOf:
         name:Digestive Diseases and Sciences
         issn:
            1573-2568
            0163-2116
         volumeNumber:56
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Qingjiang Chen
            affiliation:
                  name:Zhengzhou University
                  address:
                     name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaobing Chen
            affiliation:
                  name:The Affiliated Cancer Hospital of Zhengzhou University
                  address:
                     name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mingzhi Zhang
            affiliation:
                  name:Zhengzhou University
                  address:
                     name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Qingxia Fan
            affiliation:
                  name:Zhengzhou University
                  address:
                     name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Suxia Luo
            affiliation:
                  name:The Affiliated Cancer Hospital of Zhengzhou University
                  address:
                     name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xinguang Cao
            affiliation:
                  name:The Affiliated Cancer Hospital of Zhengzhou University
                  address:
                     name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Digestive Diseases and Sciences
      issn:
         1573-2568
         0163-2116
      volumeNumber:56
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Zhengzhou University
      address:
         name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
         type:PostalAddress
      name:The Affiliated Cancer Hospital of Zhengzhou University
      address:
         name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
         type:PostalAddress
      name:Zhengzhou University
      address:
         name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
         type:PostalAddress
      name:Zhengzhou University
      address:
         name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
         type:PostalAddress
      name:The Affiliated Cancer Hospital of Zhengzhou University
      address:
         name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
         type:PostalAddress
      name:The Affiliated Cancer Hospital of Zhengzhou University
      address:
         name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Qingjiang Chen
      affiliation:
            name:Zhengzhou University
            address:
               name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Xiaobing Chen
      affiliation:
            name:The Affiliated Cancer Hospital of Zhengzhou University
            address:
               name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Mingzhi Zhang
      affiliation:
            name:Zhengzhou University
            address:
               name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Qingxia Fan
      affiliation:
            name:Zhengzhou University
            address:
               name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Suxia Luo
      affiliation:
            name:The Affiliated Cancer Hospital of Zhengzhou University
            address:
               name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Xinguang Cao
      affiliation:
            name:The Affiliated Cancer Hospital of Zhengzhou University
            address:
               name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
      name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
      name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
      name:Department of Medicine-Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China
      name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
      name:Department of Internal Medicine-Oncology, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {šŸ”—}(132)

Analytics and Tracking {šŸ“Š}

  • Google Tag Manager

Libraries {šŸ“š}

  • Clipboard.js
  • Prism.js

Emails and Hosting {āœ‰ļø}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {šŸ“¦}

  • Crossref

4.48s.