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DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
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We began analyzing https://www.nature.com/articles/nrg2340, but it redirected us to https://www.nature.com/articles/nrg2340. The analysis below is for the second page.

Title[redir]:
Retinoic acid in development: towards an integrated view | Nature Reviews Genetics
Description:
How are the complex and varied roles of retinoic acid orchestrated at multiple developmental stages? Recent studies have highlighted the importance of tightly regulating its distribution, of switching the activities of its nuclear receptors, and of interactions with other key developmental signalling molecules. Retinoic acid (RA) has complex and pleiotropic functions during vertebrate development. Recent work in several species has increased our understanding of the roles of RA as a signalling molecule. These functions rely on a tight control of RA distribution within embryonic tissues through the combined action of synthesizing and metabolizing enzymes, possibly leading to diffusion gradients. Also important is the switching of nuclear receptors from a transcriptionally repressing state to an activating state. In addition, cross-talk with other key embryonic signals, especially fibroblast growth factors (FGFs) and sonic hedgehog (SHH), is being uncovered. Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine.

Matching Content Categories {📚}

  • Education
  • Science
  • Environment

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🏙️ Massive Traffic: 50M - 100M visitors per month


Based on our best estimate, this website will receive around 96,105,781 visitors per month in the current month.

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How Does Doi.org Make Money? {💸}

We find it hard to spot revenue streams.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, google, scholar, cas, article, retinoic, acid, development, nature, dev, embryonic, mouse, cell, cells, patterning, signaling, central, retinoid, embryo, biol, neural, signalling, heart, hindbrain, dollé, receptors, fgf, formation, essential, niederreither, genes, early, expression, raldh, forebrain, vertebrate, gene, axis, chambon, genet, synthesis, cypa, zebrafish, developing, differentiation, access, receptor, beta, function, stem,

Topics {✒️}

nature portfolio permissions reprints privacy policy author information authors tissue research advertising research regional pattern social media nature cell biol retinoic acid-metabolizing enzyme wnt/β-catenin promotes coactivator/corepressor/epigenetic code trans-retinoic acid 4-hydroxylase regulate cell-lineage decisions nature rev nature protoc nature genet integrating signal-dependent programs retinoic acid-induced downregulation controls epithelial/mesenchymal interactions nature neurosci central nervous system personal data key embryonic signals springerlink instant access nature 327 nature 340 nature 435 nature 366 nature data protection specific retinol dehydrogenase sex-specific regulation retinoic acid synthesis retinoic acid receptor article niederreither ra-dependent meiosis onset cardiac progenitor pool cardiac progenitor population embryonic retinoic acid tissue-specific catabolism karen niederreither retinoic acid signaling mesenchymal cell populations tissue-specific expression retinoic acid controls retinoic acid-inducible integrated view retinoic acid biosynthesis

Questions {❓}

  • Carotenoid and retinoid transport to fish oocytes and eggs: what is the role of retinol binding protein?

Schema {🗺️}

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         description: How are the complex and varied roles of retinoic acid orchestrated at multiple developmental stages? Recent studies have highlighted the importance of tightly regulating its distribution, of switching the activities of its nuclear receptors, and of interactions with other key developmental signalling molecules. Retinoic acid (RA) has complex and pleiotropic functions during vertebrate development. Recent work in several species has increased our understanding of the roles of RA as a signalling molecule. These functions rely on a tight control of RA distribution within embryonic tissues through the combined action of synthesizing and metabolizing enzymes, possibly leading to diffusion gradients. Also important is the switching of nuclear receptors from a transcriptionally repressing state to an activating state. In addition, cross-talk with other key embryonic signals, especially fibroblast growth factors (FGFs) and sonic hedgehog (SHH), is being uncovered. Some of these functions could be maintained throughout the life of an organism to regulate cell-lineage decisions and/or the differentiation of stem cell populations, highlighting possibilities for regenerative medicine.
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Social Networks {👍}(2)

External Links {🔗}(501)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
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Name Servers:

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  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

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