
NCBI . NLM . NIH . GOV {
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Title[redir]:
Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition - PMC
Description:
Background: Colorectal cancer (CRC) and the associated metastatic lesions are reported to be hypoxic. Hypoxia is a common feature in the tumor microenvironment and a potent stimulant of CRC. We have identified a regulatory role of Nur77 on Akt ...
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Keywords {🔍}
dicer, doi, cells, figure, expression, letip, sirna, cancer, hypoxia, google, scholar, pubmed, crc, qpcr, hct, pmc, tumor, compared, article, mirna, shrna, levels, free, transfected, mrna, luciferase, reverse, cst, mimic, hypoxic, akt, data, cell, forward, western, shown, promoter, gapdh, site, emt, metastasis, protein, binding, control, role, blotting, activity, normoxia, performed, results,
Topics {✒️}
7i-5p-p110α-akt-mtor signaling axis nur77-β-catenin feed-forward loop stabilizing hypoxia-inducible factor-1α oncogenic pi3k/akt/mtorc1 signaling downstream p110α/akt/mtorc1 play orphan receptor tr3 hypoxia-inducible factor-1α hypoxia-inducible factor 1α heat-induced antigen retrieval small-cell lung carcinoma pmc beta search web-based tool survexpress intra-tumoral oxygen level enhance β-catenin signaling unique nuclear receptor specific stem-loop primers activating tgf-β signalling m-mlv reverse transcriptase renilla luciferase-expressing plasmid nur77-regulated p110α/akt activation pi3k/akt signaling pathway kaplan-meier survival curves nuclear receptor nur77 hong kong innovation pgl3-dicer-prom plasmid high-sensitivity chip kit anti-mouse secondary antibodies technology commission grant induce nur77∆dbd interaction p110α/akt/mtor pathway pi3k/akt/mtor pathway kaplan-meier plot showed serum-free rpmi-1640 nur77/dicer/p110α axis hypoxia-induced nur77 expression serial spheroid formation 7i-5p binding site significant tumor-promoting activities [google scholar] 13 p110α mrna half-life putative p63-binding sites pgl3-dicer-promoter plasmid dicer-promoter reporter assays strongly develop secondary sphere-forming ability nur77-driven crc growth methods cell lines regulate p110α/p-akt hypoxia activated p110α/akt sphere formation assays
Questions {❓}
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- https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323 income
- https://www.nlm.nih.gov/web_policies.html's financial summary
- Financial intake of https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office
- What's the income of https://www.hhs.gov/vulnerability-disclosure-policy/index.html?
- https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal's total income per month
- What's the financial gain of https://www.nlm.nih.gov/accessibility.html?
- How much cash flow does https://www.nlm.nih.gov/careers/careers.html have monthly?
- Get to know https://www.nlm.nih.gov/'s earnings
- How much revenue does https://www.nih.gov/ generate?
- Find out how much https://www.hhs.gov/ earns monthly
- How much money does https://www.usa.gov/ generate?
Analytics and Tracking {📊}
- Google Analytics
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Libraries {📚}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
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Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
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- lhcns1.nlm.nih.gov
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CDN Services {📦}
- Ncbi