
NCBI . NLM . NIH . GOV {
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Title[redir]:
Fulvestrant plus capivasertib versus placebo after relapse or progression on an aromatase inhibitor in metastatic, oestrogen receptor-positive, HER2-negative breast cancer (FAKTION): overall survival, updated progression-free survival, and expanded biomarker analysis from a randomised, phase 2 trial - PMC
Description:
Capivasertib, an AKT inhibitor, added to fulvestrant, was previously reported to improve progression-free survival in women with aromatase inhibitor-resistant oestrogen receptor (ER)-positive, HER2-negative advanced breast cancer. The benefit ...
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Keywords {π}
participants, capivasertib, survival, cancer, pathway, fulvestrant, subgroup, doi, expanded, pathwayaltered, analysis, breast, placebo, trial, nonaltered, progressionfree, data, akt, advanced, pikaktpten, inhibitor, tumours, received, pubmed, results, tumour, months, google, scholar, faktion, treatment, group, ngs, identified, testing, pikca, primary, pten, pmc, original, phase, study, patients, therapy, mutations, status, population, article, hernegative, erpositive,
Topics {βοΈ}
pi3k/akt/pten pathway-altered er-positive pi3k/akt/pten pathway-altered status pi3k/akt/pten pathway-altered tumours expanded pi3k/akt/pten pathway-altered pi3k/akt/pten pathway activation pi3k/akt/pten signalling pathway pi3k/akt/pten pathway altered pi3k/akt/pten pathway-altered pi3k/akt/pten pathway alterations pi3k/akt/pten pathway inhibitor pi3k/akt/pten pathway deregulation Ξ±-isoform-specific pi3k inhibitor aromatase inhibitor-resistant er-positive her2-negative breast cancer her2-negative breast cancers local investigator-confirmed er-positive pi3k/akt/pten pathway interactive web-response system ngs-identified pathway-altered subgroup human breast tumours improve progression-free survival investigator-assessed progression-free survival detects single-nucleotide variations analysing progression-free survival hormone receptor-positive hormone-receptor-positive detect single-nucleotide variations pmc beta search advanced breast cancer cancer genome atlas cell-free dna [cfdna] significant progression-free survival updated progression-free survival expanded pathway-altered subgroup progression-free survival improvement her2-negative metastatic progression-free survival analysis original pathway-altered subgroup progression-free survival event median progression-free survival joint hormone receptor progression-free survival results progression-free survival benefit originally identified pathway-altered advanced er-positive metastatic breast cancers pathway-altered subgroup assigned pan-akt inhibitor capivasertib locally advanced setting oestrogen receptor-positive
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