
DOI . ORG {
}
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Title[redir]:
Frontiers | Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma
Description:
Targeting androgen receptor (AR) has been shown to be promising in treating glioblastoma (GBM) in cell culture and flank implant models but the mechanisms re...
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- Science
- Education
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Doi.org uses TYPESETTER CMS.
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🏙️ Massive Traffic: 50M - 100M visitors per month
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Keywords {🔍}
cells, cell, gbm, cancer, enzalutamide, google, scholar, doi, text, abstract, crossref, full, pubmed, expression, tumor, treatment, stem, figure, brain, umg, androgen, prostate, staining, control, patients, lines, receptor, glioblastoma, usa, mice, nanog, results, genes, vitro, spheroids, mouse, antagonists, studies, levels, mgpp, csc, showed, cscs, significantly, human, glioma, proliferation, line, marker, vivo,
Topics {✒️}
constitutively active ar-splice-variant vsvg-pseudotyped pdgf-ires-cre c-terminal ligand-binding domain aromatase-mediated testosterone conversion/depletion crispr/cas9-mediated ar knockout apc-conjugated anti-cd133 antibody data availability statement fbxw7/c-myc axis castration-resistant prostate cancer tumor sphere-forming capacities tgf-β signaling pathway tumor sphere-forming stem rare long-term survivors castration-resistant prostate cancers ligand-activated transcription factors ethics statement nuclear-dominant expression patterns anchorage-dependent cell growth stop-floxed luciferase reporter quantitative rt-pcr assays gov/geo/query/acc tumor sphere-forming cells open-access article distributed sexually-dimorphic aromatase expression tgf-β signaling pathways monoclonal anti-c-myc fluorescence-activated cell sorting aggressive prostate cancer monoclonal anti-β-actin enzalutamide downregulates c-myc quantitative rt-pcr results androgen receptor-mediated inhibition high-throughput sequencing data polyclonal anti-ar antibody c-myc expression levels ar-positive cell line orthotopic mouse model monoclonal anti-oct4 antibody promoting cell cycling/proliferation oncogene c-myc expressions cell lines derived stem cell characteristics local ethical guidelines western blotting assays tumor spheroids/cell culture human brain/gbm tissue cancer stem cell tumor-initiating capability supplementary material variable expression levels
Questions {❓}
- Do Steroid Hormones Play a Role in the Etiology of Glioma?
Schema {🗺️}
ScholarlyArticle:
context:https://schema.org
headline:Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma
author:
type:Person
name:Nan Zhao
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
type:Person
name:Fei Wang
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
type:Person
name:Shaheen Ahmed
affiliation:
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, United States
type:Person
name:Kan Liu
affiliation:
School of Biological Sciences, University of Nebraska—Lincoln, United States
type:Person
name:Chi Zhang
affiliation:
School of Biological Sciences, University of Nebraska—Lincoln, United States
type:Person
name:Sahara J. Cathcart
affiliation:
Department of Pathology and Microbiology, University of Nebraska Medical Center, United States
type:Person
name:Dominick J. DiMaio
affiliation:
Department of Pathology and Microbiology, University of Nebraska Medical Center, United States
type:Person
name:Michael Punsoni
affiliation:
Department of Pathology and Microbiology, University of Nebraska Medical Center, United States
type:Person
name:Bingjie Guan
affiliation:
Department of Radiation Oncology, Union Hospital of Fujian Medical University, China
type:Person
name:Ping Zhou
affiliation:
Department of Radiation Oncology, The First Affiliated Hospital of Hainan Medical University, China
type:Person
name:Shuo Wang
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
type:Person
name:Surinder K. Batra
affiliation:
Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, United States
type:Person
name:Tatiana Bronich
affiliation:
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, United States
type:Person
name:Tom K. Hei
affiliation:
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, United States
type:Person
name:Chi Lin
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
type:Person
name:Chi Zhang
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
datePublished:2021-05-21
dateModified:2025-07-01
publisher:
type:Organization
name:Frontiers
isPartOf:
type:PublicationIssue
datePublished:2021
isPartOf:
type:PublicationVolume
volumeNumber:11
isPartOf:
type:Periodical
name:Frontiers in Oncology
citation:
https://doi.org/10.3389/fonc.2021.616625
inLanguage:en
Person:
name:Nan Zhao
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
name:Fei Wang
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
name:Shaheen Ahmed
affiliation:
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, United States
name:Kan Liu
affiliation:
School of Biological Sciences, University of Nebraska—Lincoln, United States
name:Chi Zhang
affiliation:
School of Biological Sciences, University of Nebraska—Lincoln, United States
name:Sahara J. Cathcart
affiliation:
Department of Pathology and Microbiology, University of Nebraska Medical Center, United States
name:Dominick J. DiMaio
affiliation:
Department of Pathology and Microbiology, University of Nebraska Medical Center, United States
name:Michael Punsoni
affiliation:
Department of Pathology and Microbiology, University of Nebraska Medical Center, United States
name:Bingjie Guan
affiliation:
Department of Radiation Oncology, Union Hospital of Fujian Medical University, China
name:Ping Zhou
affiliation:
Department of Radiation Oncology, The First Affiliated Hospital of Hainan Medical University, China
name:Shuo Wang
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
name:Surinder K. Batra
affiliation:
Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute for Research in Cancer, University of Nebraska Medical Center, United States
name:Tatiana Bronich
affiliation:
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, United States
name:Tom K. Hei
affiliation:
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, United States
name:Chi Lin
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
name:Chi Zhang
affiliation:
Department of Radiation Oncology, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, United States
Organization:
name:Frontiers
PublicationIssue:
datePublished:2021
isPartOf:
type:PublicationVolume
volumeNumber:11
isPartOf:
type:Periodical
name:Frontiers in Oncology
PublicationVolume:
volumeNumber:11
isPartOf:
type:Periodical
name:Frontiers in Oncology
Periodical:
name:Frontiers in Oncology
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