
DOI . ORG {
}
Title[redir]:
Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone With Minimal Residual Disease Response-Adapted Therapy in Newly Diagnosed Multiple Myeloma | Journal of Clinical Oncology
Description:
PURPOSEThe MASTER trial combined daratumumab, carfilzomib, lenalidomide, and dexamethasone (Dara-KRd) in newly diagnosed multiple myeloma (NDMM), using minimal residual disease (MRD) by next-generation sequencing (NGS) to inform the use and duration of ...
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Keywords {🔍}
patients, mrd, therapy, myeloma, inst, google, scholar, lenalidomide, ahct, hrca, multiple, crossref, oncology, janssen, pubmed, study, treatment, disease, response, progression, mrdsure, daratumumab, dexamethasone, pfs, view, consolidation, role, birmingham, residual, cycles, research, author, sanofi, httpsorcidorg, induction, months, maintenance, minimal, newly, diagnosed, clinical, reaching, amgen, university, therapeutics, consulting, advisory, funding, mrdnegativity, fig,
Topics {✒️}
org/jco/authors/author-center asco membership mrd-adapted treatment de-escalation 63rd annual meeting mrd-guided post-ahct consolidation clinical decision-making threshold pethema/gem clinical trials autologous stem-cell transplantation asco member renew autologous stem-cell transplant 18f-fdg pet/ct medcity news timothy clopper-pearson exact method granulocyte colony-stimulating factor response-adapted treatment strategies authors disclosures luciano low-molecular weight heparin consecutive mrd-negative assessments adjudicate response-adapted therapy jco requests jco assume high-risk cytogenetic abnormalities favorites pdf journal author anita d'souza high-risk cytogenetic abnormality protocol link predict long-term outcomes high-risk multiple myeloma introduction combination therapy pairwise log-rank test large meta-analysis establishes clinical oncology stem-cell transplantation reach mrd-negativity early reach early mrd-negativity 2021 share 1200/jco jco 40 consensus guidelines authors' disclosures long-term survival outcomes entering treatment-free surveillance autologous hematopoietic cells ultra-high-risk mm ultra-high-risk patients minimal residual disease recent long-term follow initiated lenalidomide-based therapy good partial response treatment-emergent adverse event
Questions {❓}
- Szalat R, Avet-Loiseau H, Munshi NC: Gene expression profiles in myeloma: Ready for the real world?
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