
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Retinoid orphan nuclear receptor alpha (RORα) suppresses the epithelial–mesenchymal transition (EMT) by directly repressing Snail transcription - PMC
Description:
Retinoid orphan nuclear receptor alpha (RORα) is a member of the orphan nuclear factor family and regulates gene expression by binding to ROR response elements (ROREs). RORα has been identified as a potential tumor suppressor; however, how ...
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Keywords {🔍}
cells, rorα, doi, snail, emt, cancer, expression, pubmed, google, scholar, cell, mcfa, fig, pmc, article, control, breast, free, epithelial, receptor, transition, epithelialmesenchymal, transcription, protein, snai, nuclear, orphan, gene, levels, mammary, rorαexpressing, data, catalog, suppresses, potential, showed, rorαsilenced, mdamb, alpha, rores, formation, results, luciferase, rore, metastasis, growth, invasion, assay, function, images,
Topics {✒️}
pgl4-rore2-wt/pgl4-rore2-mt ros-induced epithelial-mesenchymal transition mir-18a-downregulated rora inhibits transforming growth factor-β pcdh1-rorαl-flag/shrorα vector rorα-silenced mcf10a cells exhibited retinoid-related orphan receptors wildtype/mutant pgl4-rore2 vectors longer recurrence-free survival rorα-expressing mda-mb 231 cells rorα-expressing mda-mb 157 cells pmc beta search dead-box protein ddx21 snail-/rorα-silenced mcf10a cells nf-kb-dependent activation experimental procedures antibodies mammosphere/tumorsphere-forming efficiency pgl4-rore2 vector released snail/twist-induced emt process knockdown mcf10a cell lines rorα-expressing mcf10a cells maintained double-negative feedback loop tgf-β-induced emt enhanced tumor-initiating potential tgf-β1-treated cells suppressing e-cadherin expression 100 ng/ml cholera toxin tgf-β-treated cells tgf-β1-induced downregulation rorα-expressing mda-mb 157 tracked single-cell migration rorα-expressing mcf10a cells tumorsphere-forming abilities rorα-overexpressing mcf10a cells epithelial–mesenchymal plasticity shrorα-expressing mcf10a cells proteasome-dependent protein degradation pmc copyright notice rorα-silenced mcf10a cells single-cell migration assay mir-153 inhibits epithelial ligand-dependent transcription factors supplementary materials included epidermal growth factor mcf10a cells induces single-cell migration analysis enhanced chemiluminescence system twist-expressing hmle cells akt signaling pathway tgf-β induced
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