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We began analyzing https://jhoonline.biomedcentral.com/articles/10.1186/s13045-017-0526-8, but it redirected us to https://jhoonline.biomedcentral.com/articles/10.1186/s13045-017-0526-8. The analysis below is for the second page.

Title[redir]:
A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors | Journal of Hematology & Oncology | Full Text
Description:
Background Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) the expression profile of NRs in human tissues, (2) how the NR expression is modulated during atherosclerosis and metabolic diseases, and (3) the overview of the role of NRs in inflammatory conditions are not fully understood. Methods To determine whether and how the expression of NRs are regulated in physiological/pathological conditions, we took an experimental database analysis to determine expression of all 48 known NRs in 21 human and 17 murine tissues as well as in pathological conditions. Results We made the following significant findings: (1) NRs are differentially expressed in tissues, which may be under regulation by oxygen sensors, angiogenesis pathway, stem cell master regulators, inflammasomes, and tissue hypo-/hypermethylation indexes; (2) NR sequence mutations are associated with increased risks for development of cancers and metabolic, cardiovascular, and autoimmune diseases; (3) NRs have less tendency to be upregulated than downregulated in cancers, and autoimmune and metabolic diseases, which may be regulated by inflammation pathways and mitochondrial energy enzymes; and (4) the innate immune sensor inflammasome/caspase-1 pathway regulates the expression of most NRs. Conclusions Based on our findings, we propose a new paradigm that most nuclear receptors are anti-inflammatory homeostasis-associated molecular pattern receptors (HAMPRs). Our results have provided a novel insight on NRs as therapeutic targets in metabolic diseases, inflammations, and malignancies.

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Keywords {🔍}

nrs, expression, receptors, pubmed, nuclear, google, scholar, article, tissues, receptor, cas, table, human, diseases, metabolic, mouse, expressed, tissue, genes, data, highly, gene, central, pathways, cell, yang, cells, inflammation, downregulated, fig, correlation, signaling, including, wang, results, nra, upregulated, size, full, levels, disease, shown, status, potential, arthritis, gse, antiinflammatory, activation, cancer, diabetes,

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c-fos-induced growth factor calcium-induced t-lymphocyte apoptosis initiate anti-inflammatory/homeostatic signaling immunosuppressive/anti-inflammatory cytokines directly author information authors peroxisome proliferator-activated receptor high-performance liquid chromatography nf-kb inhibitor-treated cells peroxisome proliferator-activated receptors hormone insufficiency/insensitivity/resistance oxidized low-density lipoprotein hypoxia-inducible factor 1b nucleotide-binding oligomerization domain nucleotide-binding oligomerization domain tumor necrosis factor-α specialized pro-resolving mediators hypoxia-inducible factor-1 beta lc-esi-ms/ms low-density lipoprotein receptor state privacy rights hypoxia-inducible factor 1/2-alpha transforming growth factor-β anti-inflammatory/immunosuppressive cytokines pro/anti-inflammatory cytokines anti-inflammatory cytokine pathways responsive anti-inflammatory cytokine pro-inflammatory signals suppress categorizing anti-inflammatory cytokines pro-/anti-inflammatory signaling class v-steroidogenic factor genome-wide association studies primer annealing-based approaches versus low-concentration homocysteine suppressing mapk-ap-1 pathway anti-inflammatory mechanisms include class o-miscellaneous family ligand-receptor-specific manner revealing rate-limiting steps er-α gene determines anti-inflammatory mechanisms mediated high fat diet high-fat diet retinoic acid receptor-alpha inflammasome/caspase-1 deficiency-downregulated nrs inflammasome/caspase-1 deficiency-upregulated nrs wnt/β-catenin signaling /products/ingenuity-pathway-analysis/ lps/il-1-mediated inhibition potential disease-modifying drugs conclusions based

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      headline:A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors
      description:Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) the expression profile of NRs in human tissues, (2) how the NR expression is modulated during atherosclerosis and metabolic diseases, and (3) the overview of the role of NRs in inflammatory conditions are not fully understood. To determine whether and how the expression of NRs are regulated in physiological/pathological conditions, we took an experimental database analysis to determine expression of all 48 known NRs in 21 human and 17 murine tissues as well as in pathological conditions. We made the following significant findings: (1) NRs are differentially expressed in tissues, which may be under regulation by oxygen sensors, angiogenesis pathway, stem cell master regulators, inflammasomes, and tissue hypo-/hypermethylation indexes; (2) NR sequence mutations are associated with increased risks for development of cancers and metabolic, cardiovascular, and autoimmune diseases; (3) NRs have less tendency to be upregulated than downregulated in cancers, and autoimmune and metabolic diseases, which may be regulated by inflammation pathways and mitochondrial energy enzymes; and (4) the innate immune sensor inflammasome/caspase-1 pathway regulates the expression of most NRs. Based on our findings, we propose a new paradigm that most nuclear receptors are anti-inflammatory homeostasis-associated molecular pattern receptors (HAMPRs). Our results have provided a novel insight on NRs as therapeutic targets in metabolic diseases, inflammations, and malignancies.
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         Homeostasis-associated molecular pattern receptors
         Atherosclerosis
         Metabolic disease
         Cardiovascular disease
         Oncology
         Hematology
         Cancer Research
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