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Title[redir]:
staggerer phenotype in retinoid-related orphan receptor α-deficient mice - PMC
Description:
Retinoid-related orphan receptor α (RORα) is a member of the nuclear receptor superfamily. To study its physiological role we generated null-mutant mice by targeted insertion of a lacZ reporter gene encoding the enzyme β-galactosidase. In ...
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Keywords {🔍}
rorα, mice, doi, google, scholar, pubmed, sgsg, pcs, fig, cells, cerebellum, staggerer, gene, brain, cerebellar, layer, res, phenotype, skin, cell, data, expression, motor, wildtype, test, rod, testis, hair, mouse, dna, homozygous, hanging, shown, pmc, heterozygous, βgal, animal, dendrites, receptor, expressed, recorded, equilibrium, observed, zebrin, nlm, nuclear, mutant, locus, knockout, sec,
Topics {✒️}
rorα/β-glactosidase central nervous system rorα/β-gal fusion product noti-linearized prora-koc-tk targeting construct prora-koc-tk lacz encoding β-gal β-gal gene replaced β-gal activity localized orphan nuclear receptor β-gal activity indicative climbing fiber varicosities structurally related superfamily β-gal activity gaba-labeled axon terminal orphan receptor found β-galactosidase activity climbing fiber β-gal assay graded cf-mediated epscs cf-mediated epscs elicited ror generated null-mutant mice evoked cf-epscs exhibited ligand-activated transcription factors calcium voltage-dependent conductance zebrin i-positive pcs current-clamp mode pmc beta search n-terminal domains causing purkinje cell perikaryon biological timing system cerebellar purkinje cells homozygous sg/sg mice cf-mediated epscs recorded sg/sg mice suffer immunogold-labeled axon terminals homozygous sg/sg mouse enzyme β-galactosidase β-gal adult sg/sg mice nuclear receptor superfamily zebrin i-immunostained pcs zebrin i-immunoreactive pcs mossy fiber rosette sg/sg mice exhibit null-mutant animals tissue-specific differentiation programs anti-gaba antibodies cf-mediated epscs pc perikarya abut
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