
NCBI . NLM . NIH . GOV {
}
Title[redir]:
The estrogen receptor variants β2 and β5 induce stem cell characteristics and chemotherapy resistance in prostate cancer through activation of hypoxic signaling - PMC
Description:
Chemotherapy resistant prostate cancer is a major clinical problem. When the prostate cancer has become androgen deprivation resistant, one of the few treatment regimens left is chemotherapy. There is a strong connection between a cancer’s stem cell ...
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Keywords {🔍}
erβ, cancer, doi, cells, cell, prostate, pubmed, google, scholar, expression, development, hifα, variants, stem, pmc, chemotherapy, cellular, article, shown, free, resistance, figure, function, abcg, regulated, protein, system, transcripts, hypoxia, control, signaling, expressing, receptor, increased, estrogen, rnaseq, level, survival, proliferation, tissue, organismal, genes, data, analysis, disease, rna, wang, gene, performed, oncotarget,
Topics {✒️}
androgen deprivation therapy epithelial-mesenchymal transition androgen deprivation resistant truncated ligand-binding domain truncated ligand-binding-domain oestrogen-receptor-beta-targeted therapy castration-resistant prostate cancer estrogen-related receptor beta md anderson ligand binding pocket adt crpc ere serm anderson cancer center actin-binding protein caldesmon pmc beta search mammary epithelial cell truncated lbd estrogen receptor beta2 houstonseq-n-edit core fast gapped-read alignment mda pcapdxs series hif-1α response elements mda pca pdxs rna-seq alignment app estrogen receptor β2 14c8 n-terminal antibody hormone-refractory prostate cancer c-kit ligand p38/nf-kappab signaling prostate cancer pdx �prostate cancer pdx” hormone therapy intracellular domain qiagen rna-easy kit inhibit nf-kb signaling lbd patient outcome small c-terminal peptide estrogen receptors β1 mdr gene full length receptor estrogen receptor erβ5-expressing pc3 cells tgf-β signaling hif-1α independent mechanism immunoprecipitated hif-1α protein nf-κb signaling correlates rna-seq library preparation
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