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We began analyzing https://www.tandfonline.com/doi/full/10.1517/17425255.4.7.895, but it redirected us to https://www.tandfonline.com/doi/full/10.1517/17425255.4.7.895. The analysis below is for the second page.

Title[redir]:
The pregnane X receptor: from bench to bedside: Expert Opinion on Drug Metabolism & Toxicology: Vol 4 , No 7 - Get Access
Description:
1. The pregnane X receptor (PXR; NR1I2), identified in 1998 as a member of the nuclear receptor superfamily, is expressed in liver and intestine and in front-line organs involved in the absorption,...

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Keywords {🔍}

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Topics {✒️}

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Schema {🗺️}

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PublicationIssue:
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ScholarlyArticle:
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      articleSection:Review
      name:The pregnane X receptor: from bench to bedside
      headline:The pregnane X receptor: from bench to bedside
      abstract:Background: The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters involved in the response of mammals to their chemical environment. Objective: To summarize the functions and clinical implications of PXR. Methods: In the current review, the clinical implications of PXR are discussed, and the use of genetically engineered PXR mouse models is highlighted. Results/conclusion: Recent advances in mouse models, including Pxr-null and PXR-humanized mice, provide in vivo tools for evaluating the physiological functions of PXR and its role in controlling xenobiotic metabolism and transport. By using the PXR knockout and humanized mouse models, PXR was found to influence drug–drug interactions, hepatic steatosis, and the homeostasis of vitamin D, bile acids, and steroid hormones. PXR was also shown to influence inflammatory bowel diseases.
      description:Background: The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of metabolic enzymes and transporters involved in the response of mammals to their chemical environment. Objective: To summarize the functions and clinical implications of PXR. Methods: In the current review, the clinical implications of PXR are discussed, and the use of genetically engineered PXR mouse models is highlighted. Results/conclusion: Recent advances in mouse models, including Pxr-null and PXR-humanized mice, provide in vivo tools for evaluating the physiological functions of PXR and its role in controlling xenobiotic metabolism and transport. By using the PXR knockout and humanized mouse models, PXR was found to influence drug–drug interactions, hepatic steatosis, and the homeostasis of vitamin D, bile acids, and steroid hormones. PXR was also shown to influence inflammatory bowel diseases.
      author:
            type:Person
            name:Frank J Gonzalez
            type:Person
            name:Xiaochao Ma
            type:Person
            name:Jeffrey R Idle
      keywords:Pxr-null mouse, PXR-humanized mouse, pregnane X receptor, nuclear receptor, clinical implications
      pageStart:895
      pageEnd:908
      datePublished:2008-07-15
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         name:Taylor & Francis
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