
NCBI . NLM . NIH . GOV {
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Title[redir]:
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression - PMC
Description:
The transcription factor NF-κB is activated in a range of human cancers and is thought to promote tumorigenesis, mainly due to its ability to protect transformed cells from apoptosis. To investigate the role of NF-κB in epithelial plasticity and ...
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Keywords {🔍}
cells, nfκb, epras, doi, tgfβ, emt, activity, pubmed, google, scholar, figure, expression, cell, control, eprasxt, epithelial, metastasis, tdiκbα, tumor, days, cancer, structures, apoptosis, signaling, mesenchymal, shown, induction, genes, inhibition, vimentin, caikk, ecadherin, mice, collagen, analysis, mammary, empty, human, activation, expressing, infected, tdiκbαexpressing, levels, porous, role, observed, pmc, transcription, ras, tumors,
Topics {✒️}
benzyloxycarbonyl-val-ala-asp-fluoromethyl-ketone overlapping ap-2/nf-κb-responsive elements org/cgi/content/full/114/4/569/dc1 ikk/iκbα/nf-κb signaling module nf-κb gene nf-κb2/p52 td-iκβα–expressing epras cells polyclonal rabbit anti–e-cadherin ikk-2/iκbα/nf-κb pathway plays td-iκbα–expressing epras cells td-iκbα–expressing epras cultures β-globin-tata reporter construct β-globin-tata reporter constructs td-iκbα–overexpressing epras cells nf-κb–dependent metastatic capacity td-iκbα–expressing cells reverted nf-κb–dependent luciferase reporter td-iκbα–expressing eprasxt cells td-iκbα–expressing virus nf-κb dna-binding activity gfp–zeocin-resistance fusion gene rel/nf-κb transcription factors tgf-β–induced gene program ca–ikk-2–expressing epras cells untreated ca–ikk-2–expressing cells ca–ikk-2–expressing v12s35ras cells ca–ikk-2–overexpressing epras cells nf-κb–regulated genes induced ikk-2/iκbα/nf-κb pathway tgf-β–dependent signaling pathways late-stage mammary tumorigenesis induces hyperactive erk/mapk 25 μm z-vad-fmk nuclear factor-κb-mediated induction epstein-barr virus transformation nf-κb–regulated target genes td-iκbα–expressing structures td-iκbα–expressing cells retroviruses expressing td-iκbα td-iκbα–expressing derivatives enhanced anti-tumor therapy aberrant rel/nfkb genes late-stage tumor progression td-iκbα cells showed raf/mek/mapk pathway raf/mek/erk pathway aberrant nf-κb activity tgf-β–dependent apoptosis induction nf-κb activity abrogated weakly expressing e-cadherin exogenous td-iκbα resulted
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