
NCBI . NLM . NIH . GOV {
}
Title[redir]:
RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis - PMC
Description:
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, and the worldwide prevalence of IBD rapidly continues to rise. It has been widely accepted that genetic predisposition remains an important risk ...
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Keywords {🔍}
rorα, mice, rorαδiec, nfκb, fig, genes, iecs, doi, pubmed, google, scholar, intestinal, rorαff, inflammatory, target, inflammation, cell, pmc, expression, article, dss, free, transcriptional, gene, activity, analysis, colitis, hdac, dssinjured, signaling, promoters, data, regeneration, homeostasis, immune, treatment, tissue, dssinduced, day, brd, performed, group, attenuation, shown, appendix, cluster, response, epithelial, levels, epithelium,
Topics {✒️}
pkcα-lsd1-nf-κb-signaling cascade peroxisome proliferator-activated receptor-γ repressing wnt/β-catenin signaling pgc-1alpha-responsive genes involved retinoid-related orphan receptors intestine-specific rorα-deficient mice specific pathogen-free association tnf-α–treated murine organoids pmc beta search attenuate nf-κb signaling inducible cre-mediated recombination genome-wide cdna microarrays inhibiting nf-κb activation p65/brd4/cbp coactivator complexes attenuating nf-κb signaling nf-κb/nlrp3 connection suppress nf-κb signaling org/lookup/suppl/doi commensal-host immune crosstalk tumor necrosis factor-α nf-κb target promoters nf-κb signaling controls rorα-deficient mice exhibited quantitative real-time pcr nf-κb transcriptional activity genome-wide association studies nf-κb target genes mice expressing cre-recombinase iec-specific rorα-deficient nf-kappab signaling pathway genome-wide transcriptome analysis ovalbumin-induced lung inflammation allergen-induced lung inflammation p65-mediated transcriptional activities rorα-mediated transcriptional repression pathogen-mediated posttranslational modifications tnf-α–induced disruption rorα-deficient organoids compared cell cycle-related terms nuclear receptors rev-erbs dss-driven intestinal inflammation tnf-α treatment induced dna damage-induced rorα dextran sulfate sodium p50-p65 heterodimer serves nf-kappab transcription factors dss-injured rorαδiec mice representative bright-field images dss-induced intestinal inflammation lipopolysaccharide-induced lung inflammation
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