
NCBI . NLM . NIH . GOV {
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Title[redir]:
ERα-LBD, an isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance - PMC
Description:
Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is a widely ...
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Keywords {🔍}
doi, cells, erαlbd, data, erα, cancer, cell, breast, fig, supplementary, usa, expression, pubmed, google, scholar, fulvestrant, pmc, article, protein, mcf, free, analysis, erαfl, esr, samples, resistance, models, tnbc, min, transcript, esrlbd, estrogen, compared, mdamb, growth, gene, exon, receptor, signaling, mitochondrial, rna, tumors, levels, performed, rnaseq, endocrine, treatment, fulvres, source, cancers,
Topics {✒️}
3x-ere-tata-luciferase reporter plasmid lc-ms/ms analysis lc-ms/ms c18 resin-packed stage-tips high-fat-fed ovariectomized mice rna-seq fastq files p-esr1-lbd reporter plasmids financial competing interests competing financial interests sample-specific dual-indexes primers human estrogen receptor-alpha36 human estrogen receptor-alpha66 fccp p-trifluoromethoxy-phenylhydrazone tibialis posterior/popliteal muscles mda-mb-453/-231 erα-lbdkd “loss unlike full-length erα reduces erα full-length candidate cis-regulatory elements preventing uv-induced apoptosis mda-mb-453 erα-lbdoe cells mda-mb-231 erα-lbdoe cells pmc beta search lc-ms/ms analysis competing interests high-throughput sequencing data hormone-resistant breast cancer esr1-lbd transcript ranges methods cell culture triple-negative breast cancer hormone binding-mediated conformational footnotes publisher preferentially bind erα-lbd stabilize erα-lbd akin license information pmcid triple-negative breast cancers css charcoal-stripped serum er-regulated transcriptional programs java treeview–extensible visualization rna-seq results affects beta-oxidation activity including supplementary information transcriptomics introduction 12% sds–page heat map showing erα-fl expressing mcf-7 accession numbers e-mtab-10733 putative promoter experiment rna-seq analysis led rna capture-sequencing experiments erα-lbd protein interactors data availability statements
Questions {❓}
- Receptors, associations, and risk factor differences by breast cancer subtypes: positive or negative?
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