
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Increased Chemosensitivity via Targeting Testicular Nuclear Receptor 4 (TR4)-Oct4-Interleukin 1 Receptor Antagonist (IL1Ra) Axis in Prostate Cancer CD133+ Stem/Progenitor Cells to Battle Prostate Cancer - PMC
Description:
Background: PCa stem/progenitor cells develop higher chemoresistance. Results: High TR4 levels in PCa stem/progenitor cells were shown to be critical in conferring chemoresistance to these cells. Conclusion: TR4-Oct4-IL1Ra signaling is important in ...
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Keywords {🔍}
cells, cancer, pca, stemprogenitor, doi, pubmed, google, scholar, docetaxel, prostate, cell, chemoresistance, oct, stem, pmc, drug, expression, article, patients, results, resistance, free, knockdown, chemotherapy, fig, ccd, receptor, genes, level, nonstemprogenitor, etoposide, metastatic, protein, liu, ilra, shown, compared, line, therapy, oncol, higher, found, showed, treatment, pcscs, analysis, nuclear, chen, control, assay,
Topics {✒️}
excellence grant doh99-td-b-111-004 c4-2/cd133+ pca stem/progenitor c4-2/cd133+ stem/progenitor cells castration-resistant prostate cancer targeting p38/p53/p21 signaling c4-2sitr4-cd133+ cell culture prostate tumor-initiating cells prostate carcinoma-initiating stem stem/progenitor marker expressions hormone-refractory prostate cancer c4-2/cd133+ stem/progenitor keratinocyte serum-free media pca stem/progenitor cells stem/progenitor cell differentiation p38/p53/p21 signaling drug-resistant pca cells hormone-sensitive prostate cancer c4-2sc-cd133+ cells isolated cd133+ stem/progenitor cd133+ stem/progenitor cells adenine nucleotide-independent mechanism c4-2sitr4-cd133+ cells retinoic acid receptor/retinoid stem/progenitor cells led docetaxel-resistant crpc patients tr4-oct4-il1ra signal axis metastatic prostate cancer drug-resistant related genes pmc beta search tumor initiating cells ionizing radiation-induced damage pmc copyright notice applied neutralization/interruption approaches tumor initiating prostatospheres pca cell lines bio-rad cfx96 system stem/progenitor cell rescuing reduced pcsc prostate cancer cells taxel-related chemoresistance genes cancer-related death c4-2sc-cd133+ early reports showed advanced prostate cancer metastatic crpc stem/progenitor cells stem/progenitor cells c4-2sitr4-cd133+ cancer stem cells c4-2/cd133+ cells
Questions {❓}
- (2010) Why not treat human cancer with interleukin-1 blockade?
- Clinical evidence for cross-resistance?
- Does sequence matter?
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- How much does https://scholar.google.com/scholar_lookup?journal=Cancer%20Biol.%20Ther&title=Calcitonin%20induces%20apoptosis%20resistance%20in%20prostate%20cancer%20cell%20lines%20against%20cytotoxic%20drugs%20via%20the%20Akt/survivin%20pathway&author=S.%20Thomas&author=G.%20Shah&volume=4&publication_year=2005&pages=1226-1233&pmid=16222118&doi=10.4161/cbt.4.11.2093& earn?
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