
NCBI . NLM . NIH . GOV {
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Title[redir]:
Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma - PMC
Description:
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis and chemotherapy with gemcitabine has limited effects and is associated with development of drug resistance. Treatment of Panc1 and MiaPaca2 pancreatic cancer ...
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Keywords {🔍}
nurr, cells, atg, gemcitabine, cancer, fig, expression, cdim, doi, pancreatic, pubmed, google, scholar, cell, pmc, autophagy, miapaca, article, survival, analysis, free, tumor, treatment, tumors, data, pda, mmoll, drug, resistance, combination, receptor, control, nuclear, patients, treated, nurrko, supplementary, genes, growth, experiments, mice, role, knockdown, results, compared, performed, enhanced, nra, immunoblot, independent,
Topics {✒️}
ets2/mirna196b/foxo1/p27 axis crispr/cas9 gene–edited cells strand-specific rna-sequencing punctate egfp-lc3 structures n-terminal activation domain agt12 promoter-luciferase constructs bis-indole–derived c-dim12 hausser bright-line hemocytometer pmc beta search crispr/cas9–mediated knockout egfp-lc3 punctate staining average egfp-lc3 punctate lc3-ii punctate staining 150-bp paired-end format crispr/cas9 gene editing c-dim12–treated miapaca2 cells c-dim12–treated panc1 cells kaplan–meier analysis shows kaplan–meier survival analysis squamous cell carcinoma publisher site pdf c-dim12 decreased expression methods cell lines supplementary table s1 luciferase reporter plasmid c-dim12–induced apoptosis nurr1 antagonist c-dim12 autophagic marker lc3b-ii identify nurr1-regulated genes blocked nurr1-mediated responses progression-free survival wild-type idh1 orphan nuclear receptors athymic nude mice authors' disclosures disease-free survival guide rna sequences orphan nuclear receptor transmission electron microscopy data availability statements supplementary materials included gemcitabine-induced cytoprotective autophagy pancreatic ductal adenocarcinoma advanced pancreatic cancer nuclear receptor 4a2 ultra-thin sections nih p30-es029067 gemcitabine-induced drug resistance renilla luciferase activity firefly luciferase activity
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