
NCBI . NLM . NIH . GOV {
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Title[redir]:
Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist - PMC
Description:
Ovarian cancer (OCa) is the deadliest gynecologic cancer. Emerging studies suggest ovarian cancer stem cells (OCSCs) contribute to chemotherapy resistance and tumor relapse. Recent studies demonstrated estrogen receptor beta (ERฮฒ) exerts tumor ...
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Keywords {๐}
erฮฒ, doi, ocscs, cells, cancer, scholar, google, pubmed, cell, expression, pmc, estrogen, agonist, article, free, treatment, ovarian, receptor, tumor, genes, treated, stem, oca, fdxr, apoptosis, figure, vehicle, aldhve, skov, results, gene, beta, reduced, analysis, determined, cat, shown, data, usa, expressed, cycle, isoforms, showed, target, studies, stemness, significantly, chemotherapy, enriched, sphere,
Topics {โ๏ธ}
informed consent statement mitochondrial fe-s-synthesis diseases ere-luc reporter assays stable expressing gfp-luc ligand-binding domains differ estrogen receptor beta-beta ere-luc reporter activity pmc beta search cell-titer-glo reagent delta-delta-ct method iron-sulfur cluster biogenesis data availability statement nih-nci p30 ca054174 cell-titer-glo assay promote extra-nuclear signaling published chip-seq profiles late-onset breast cancer estrogen receptor-beta expression patient-derived aml cells dmem-f12 medium supplemented erฮฒ chip-seq profile understanding er-beta signaling ultra-low attachment plates large-scale expression profiling hrp-conjugated secondary antibody ncr/scid female mice ovarian cancer-initiating cells cell type-specific regulation rna-sequencing data showed tissue-specific tumor suppressor aldh+ve populations isolated a2780- aldh+ve cells aldh+ve cells enriched rt-qpcr results showed rt-qpcr assays demonstrated cell/tissue specific function aldh+ve cells compared rna-seq analysis demonstrated estrogen receptor beta matrigel invasion assays p21 waf1/cip1 gene supplementary materials included primary human tumors chip-seq profiles skov3 aldh+ve cells estrogen receptor ฮฒ publisher site pdf stem/progenitor cells [43] [google scholar] 4 oestrogen receptor beta
Questions {โ}
- The expression and clinical significance of ERฮฒ/ERฮฑ in ovarian cancer: Can we predict the effectiveness of platinum plus taxane therapy?
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