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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

pubmed, google, scholar, doi, receptor, nuclear, receptors, pmc, article, free, nrs, dna, binding, ligand, ligands, domain, cell, structure, mol, structural, orphan, proteins, biol, fig, lbd, structures, transcription, factor, interactions, complex, gene, transcriptional, coregulator, response, retinoic, acid, function, lrh, type, activation, hormone, bind, elements, rev, region, dbd, dynamics, studies, domains, heterodimer,

Topics {✒️}

sumo‐smrt/ncor1‐hdac3 repressing complex peroxisome proliferator‐activated receptor‐gamma orphan estrogen‐related receptor‐γ peroxisome proliferator‐activated receptor‐α orphan estrogen‐related receptor‐β cryo‐electron microscopy retinoic acid‐related orphan‐α direct glucocorticoid‐mediated transrepression peroxisome proliferator‐activated receptor single particle cryo‐em single‐particle cryo‐em single‐molecule tracking rxr‐rar dna‐binding complex estrogen‐related receptor‐α thyroid hormone receptor‐α neuron‐derived orphan receptor‐1 single‐molecule experiments revealed single‐molecule experiments hold retinoic acid receptor‐α hepatocyte nuclear factor‐4‐α sequence‐specific deoxyribonucleic acid estrogens estrogen receptor‐β cholesterol‐derived steroidal hormones define tf–chromatin interactions sequence‐specific dna association widespread nr‐chromatin occupancy ligand‐activated estrogen receptors cryo‐em studies due node‐negative breast cancer nuclear receptor‐coactivator interactions pmc beta search experimental hdx‐ms data rxr‐rar dbd heterodimer current fda‐approved drugs vivo chip‐seq collected make base‐specific contacts make base‐specific interactions thyroid hormones 1b providing cross‐platform confirmation nuclear receptor‐corepressor interaction rxrbeta ligand‐binding domains allosteric domain positioning combine high‐resolution structural agonist‐liganded glucocorticoid receptor nr‐targeting ligands make heme reverse‐erb‐β single‐molecule studies support nurr‐related factor‐1 alternative side‐chain conformation adrenal gland led

Questions {❓}

• Can we have a more continuous picture of NR function in vivo, capturing both association with DNA and recruitment of co‐regulators, beyond the discrete structural snapshots we currently have?
• Stasevich TJ, McNally JG (2011) Assembly of the transcription machinery: ordered and stable, random and dynamic, or both?
• Tetel MJ, Auger AP, Charlier TD (2009) Who's in charge?

Social Networks {👍}(6)

• https://twitter.com/ncbi
• https://www.facebook.com/ncbi.nlm
• https://www.linkedin.com/company/ncbinlm
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• https://www.facebook.com/nationallibraryofmedicine
• https://www.youtube.com/user/NLMNIH

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• Revenue of https://doi.org/10.1038/cr.2014.52
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• What are the earnings of https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=X%E2%80%90ray%20crystal%20structure%20of%20the%20liver%20X%20receptor%20beta%20ligand%20binding%20domain:%20regulation%20by%20a%20histidine%E2%80%90tryptophan%20switch&author=S%20Williams&author=RK%20Bledsoe&author=JL%20Collins&author=S%20Boggs&author=MH%20Lambert&volume=278&publication_year=2003&pages=27138-27143&pmid=12736258&doi=10.1074/jbc.M302260200&?
• What's the financial outcome of https://doi.org/10.1021/acschembio.6b00338?
• How much income is https://scholar.google.com/scholar_lookup?journal=ACS%20Chem%20Biol&title=17%E2%80%90OxoDHA%20is%20a%20PPARalpha/gamma%20dual%20covalent%20modifier%20and%20agonist&author=D%20Egawa&author=T%20Itoh&author=Y%20Akiyama&author=T%20Saito&author=K%20Yamamoto&volume=11&publication_year=2016&pages=2447-2455&pmid=27337155&doi=10.1021/acschembio.6b00338& earning monthly?
• Income figures for https://doi.org/10.1016/0968-0004(91)90121-b
• https://scholar.google.com/scholar_lookup?journal=Trends%20Biochem%20Sci&title=Beyond%20zinc%20fingers:%20steroid%20hormone%20receptors%20have%20a%20novel%20structural%20motif%20for%20DNA%20recognition&author=JW%20Schwabe&author=D%20Rhodes&volume=16&publication_year=1991&pages=291-296&pmid=1957350&doi=10.1016/0968-0004(91)90121-b&'s financial summary
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• What's the income generated by https://doi.org/10.1016/s0969-2126(01)00150-2 each month?
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• Check the income stats for https://doi.org/10.1038/375203a0
• How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=Structural%20determinants%20of%20nuclear%20receptor%20assembly%20on%20DNA%20direct%20repeats&author=F%20Rastinejad&author=T%20Perlmann&author=RM%20Evans&author=PB%20Sigler&volume=375&publication_year=1995&pages=203-211&pmid=7746322&doi=10.1038/375203a0& net monthly?
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• What's the financial intake of https://doi.org/10.1210/me.2005-0384?
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• How profitable is https://doi.org/10.1038/47069?
• Revenue of https://scholar.google.com/scholar_lookup?journal=Nature&title=The%20CoRNR%20motif%20controls%20the%20recruitment%20of%20corepressors%20by%20nuclear%20hormone%20receptors&author=X%20Hu&author=MA%20Lazar&volume=402&publication_year=1999&pages=93-96&pmid=10573424&doi=10.1038/47069&
• How much profit does https://doi.org/10.1210/mend.14.12.0566 generate?
• What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Mol%20Endocrinol&title=The%20nuclear%20receptor%20corepressor%20(N%E2%80%90CoR)%20contains%20three%20isoleucine%20motifs%20(I/LXXII)%20that%20serve%20as%20receptor%20interaction%20domains%20(IDs)&author=P%20Webb&author=CM%20Anderson&author=C%20Valentine&author=P%20Nguyen&author=A%20Marimuthu&volume=14&publication_year=2000&pages=1976-1985&pmid=11117528&doi=10.1210/mend.14.12.0566&?
• How much income does https://doi.org/10.1101/gad.13.24.3209 have?
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=Mechanism%20of%20corepressor%20binding%20and%20release%20from%20nuclear%20hormone%20receptors&author=L%20Nagy&author=HY%20Kao&author=JD%20Love&author=C%20Li&author=E%20Banayo&volume=13&publication_year=1999&pages=3209-3216&pmid=10617570&doi=10.1101/gad.13.24.3209& bring in?
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• Monthly income for https://scholar.google.com/scholar_lookup?journal=Genes%20Dev&title=Molecular%20determinants%20of%20nuclear%20receptor%E2%80%90corepressor%20interaction&author=V%20Perissi&author=LM%20Staszewski&author=EM%20McInerney&author=R%20Kurokawa&author=A%20Krones&volume=13&publication_year=1999&pages=3198-3208&pmid=10617569&doi=10.1101/gad.13.24.3198&
• What is the monthly revenue of https://doi.org/10.1210/mend.16.5.0823?
• How much does https://scholar.google.com/scholar_lookup?journal=Mol%20Endocrinol&title=Molecular%20recognition%20of%20agonist%20ligands%20by%20RXRs&author=PF%20Egea&author=A%20Mitschler&author=D%20Moras&volume=16&publication_year=2002&pages=987-997&pmid=11981034&doi=10.1210/mend.16.5.0823& pull in?
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• What's the financial intake of https://doi.org/10.1038/378681a0?
• Earnings of https://scholar.google.com/scholar_lookup?journal=Nature&title=Crystal%20structure%20of%20the%20RAR%E2%80%90gamma%20ligand%E2%80%90binding%20domain%20bound%20to%20all%E2%80%90trans%20retinoic%20acid&author=JP%20Renaud&author=N%20Rochel&author=M%20Ruff&author=V%20Vivat&author=P%20Chambon&volume=378&publication_year=1995&pages=681-689&pmid=7501014&doi=10.1038/378681a0&
• What's the monthly money flow for https://doi.org/10.1074/jbc.M115.662874?
• How much money does https://scholar.google.com/scholar_lookup?journal=J%20Biol%20Chem&title=Unexpected%20allosteric%20network%20contributes%20to%20LRH%E2%80%901%20co%E2%80%90regulator%20selectivity&author=PM%20Musille&author=BR%20Kossmann&author=JA%20Kohn&author=I%20Ivanov&author=EA%20Ortlund&volume=291&publication_year=2016&pages=1411-1426&pmid=26553876&doi=10.1074/jbc.M115.662874& generate?
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• How much profit is https://doi.org/10.1016/j.str.2011.10.018 making per month?
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• How much income does https://doi.org/10.1095/biolreprod46.2.163 have?
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• Income figures for https://doi.org/10.1042/bse0400041
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• What's the total monthly financial gain of https://doi.org/10.1517/14728222.7.5.679?
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• https://doi.org/10.1097/MJT.0b013e3181c08081's financial summary
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• https://doi.org/10.1124/pr.112.006833's total income per month
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Pharmacol%20Rev&title=Nuclear%20receptors%20and%20their%20selective%20pharmacologic%20modulators&author=TP%20Burris&author=LA%20Solt&author=Y%20Wang&author=C%20Crumbley&author=S%20Banerjee&volume=65&publication_year=2013&pages=710-778&pmid=23457206&doi=10.1124/pr.112.006833&?
• What's the financial intake of https://doi.org/10.1016/j.pharmthera.2011.12.004?
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• Revenue of https://doi.org/10.1590/s0004-27302006000400017
• What's the financial intake of https://scholar.google.com/scholar_lookup?journal=Arq%20Bras%20Endocrinol%20Metabol&title=Selective%20estrogen%20receptor%20modulators%20(SERMS)&author=A%20Diez%E2%80%90Perez&volume=50&publication_year=2006&pages=720-734&pmid=17117297&doi=10.1590/s0004-27302006000400017&?
• Profit of https://doi.org/10.1016/j.sbi.2003.10.008
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• What's the profit of https://doi.org/10.1016/j.sbi.2010.10.007?
• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Curr%20Opin%20Struct%20Biol&title=Protein%20dynamics%20and%20allostery:%20an%20NMR%20view&author=SR%20Tzeng&author=CG%20Kalodimos&volume=21&publication_year=2011&pages=62-67&pmid=21109422&doi=10.1016/j.sbi.2010.10.007&?
• How much money does https://doi.org/10.1038/ncomms9013 make?
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• Learn about the earnings of https://doi.org/10.1038/nature09291
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Nature&title=Anti%E2%80%90diabetic%20drugs%20inhibit%20obesity%E2%80%90linked%20phosphorylation%20of%20PPARgamma%20by%20Cdk5&author=JH%20Choi&author=AS%20Banks&author=JL%20Estall&author=S%20Kajimura&author=P%20Bostrom&volume=466&publication_year=2010&pages=451-456&pmid=20651683&doi=10.1038/nature09291& bring in?
• What's the total monthly financial gain of https://doi.org/10.1124/mol.112.079285?
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