
NCBI . NLM . NIH . GOV {
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Title[redir]:
Pregnane X-receptor promotes stem cell-mediated colon cancer relapse - PMC
Description:
Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanced resistance of Cancer Stem Cells (CSCs). Here, we show that the nuclear receptor Pregnane X Receptor (PXR, NR1I2), ...
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Keywords {🔍}
cells, pxr, doi, expression, cancer, figure, pubmed, google, scholar, tumor, crc, stem, cscs, cell, pmc, aldhbr, article, aldha, free, csc, compared, colon, tumors, supplementary, activity, genes, colorectal, chemotherapy, data, treatment, patients, human, expressed, mrna, gene, pii, results, receptor, mice, recurrence, shluc, chemoresistance, sem, control, shpxr, enhanced, survival, day, higher, resistance,
Topics {✒️}
log-rank mantel-cox test aldh1a/human mitochondria-stained areas gfp-tagged pxr-driven promoter human colon-cancer-initiating cells wnt signaling pathway poor recurrence-free survival csc-mediated tumor recurrence sirna-mediated pxr depletion chemotherapy-induced csc enrichment pmc beta search stage ii-iv patients atp-binding cassette g2 luciferase/β-galactosidase ratio aldehyde dehydrogenase 1a1 aldehyde dehydrogenase 1a1 folfiri-resistant tumor cells 5′fluoruracil-based adjuvant chemotherapy enhanced anti-apoptotic capabilities patient-derived crc cells post-chemotherapy tumour recurrence poor-prognosis molecular signature selective pxr-signaling inhibitors human pancreatic adenocarcinoma eif1α-gfp low cells supplementary materials oncotarget-07-56558-s001 disease-free survival β-actin protein expression kaplan–meier survival plots rt-qpcr analyses revealed folfiri-treated tumor xenografts supplementary figure s1b-s1d supplementary tables s2&s3 residual folfiri-treated shluc shpxr-derived tumors cells folfiri-treated control tumors folfiri-treated shpxr tumors pxr decreases csc post-treatment tumor recurrence folfiri-treated shluc tumors vivo tumor-initiating potential vivo tumor–initiating potential cancer stem cell cell stem cell folfiri-treated shpxr group eif1α-gfp br cells cyp3a4-egfp infected cells higher sphere-forming efficiency targeting pxr expression/activity iii patients treated enhanced spheroid-forming efficiency
Questions {❓}
- Treatment in advanced colorectal cancer: what when and how?
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- https://scholar.google.com/scholar_lookup?journal=Anticancer%20Res&title=The%20combination%20of%205-FU%20leucovorin%20and%20CPT-11%20(FOLFIRI)%20prolongs%20survival%20through%20inhibition%20of%20metastasis%20in%20an%20orthotopic%20model%20of%20colon%20cancer&author=Y%20Ishihara&author=K%20Matsunaga&author=H%20Iijima&author=G%20Hasegawa&author=T%20Suzuki&volume=30&publication_year=2010&pages=403-8&pmid=20332446&'s financial summary
- Financial intake of https://doi.org/10.3892/ol.2013.1149
- Income figures for https://scholar.google.com/scholar_lookup?journal=Oncol%20Lett&title=Expression%20of%20the%20PXR%20gene%20in%20various%20types%20of%20cancer%20and%20drug%20resistance&author=E%20Qiao&author=M%20Ji&author=J%20Wu&author=R%20Ma&author=X%20Zhang&volume=5&publication_year=2013&pages=1093-100&pmid=23599746&doi=10.3892/ol.2013.1149&
- https://doi.org/10.1038/sj.bjc.6606064's financial summary
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Br%20J%20Cancer&title=Constitutive%20androstane%20receptor%20agonist%20CITCO%20inhibits%20growth%20and%20expansion%20of%20brain%20tumour%20stem%20cells&author=S%20Chakraborty&author=S%20Kanakasabai&author=JJ%20Bright&volume=104&publication_year=2011&pages=448-59&pmid=21224854&doi=10.1038/sj.bjc.6606064&?
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- What's the financial gain of https://doi.org/10.18632/oncotarget.6920?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Oncotarget&title=Aldehyde%20dehydrogenase%201A1%20in%20stem%20cells%20and%20cancer&author=H%20Tomita&author=K%20Tanaka&author=T%20Tanaka&author=A%20Hara&volume=7&publication_year=2016&pages=11018-32&pmid=26783961&doi=10.18632/oncotarget.6920&?
- https://doi.org/10.1093/nar/gkq654's financial summary
- How much profit does https://scholar.google.com/scholar_lookup?journal=Nucleic%20Acids%20Res&title=ChIPing%20the%20cistrome%20of%20PXR%20in%20mouse%20liver&author=JY%20Cui&author=SS%20Gunewardena&author=CE%20Rockwell&author=CD%20Klaassen&volume=38&publication_year=2010&pages=7943-63&pmid=20693526&doi=10.1093/nar/gkq654& make?
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- Earnings of https://doi.org/10.1016/j.bcp.2011.08.023
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Biochem%20Pharmacol&title=Metformin%20suppresses%20pregnane%20X%20receptor%20(PXR)-regulated%20transactivation%20of%20CYP3A4%20gene&author=L%20Krausova&author=L%20Stejskalova&author=H%20Wang&author=R%20Vrzal&author=Z%20Dvorak&volume=82&publication_year=2011&pages=1771-80&pmid=21920351&doi=10.1016/j.bcp.2011.08.023&
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- What's the total monthly financial gain of https://doi.org/10.1158/0008-5472.CAN-09-1132?
- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Aldehyde%20dehydrogenase-expressing%20colon%20stem%20cells%20contribute%20to%20tumorigenesis%20in%20the%20transition%20from%20colitis%20to%20cancer&author=JE%20Carpentino&author=MJ%20Hynes&author=HD%20Appelman&author=T%20Zheng&author=DA%20Steindler&volume=69&publication_year=2009&pages=8208-15&pmid=19808966&doi=10.1158/0008-5472.CAN-09-1132& have monthly?
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