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We began analyzing https://www.nature.com/articles/32918, but it redirected us to https://www.nature.com/articles/32918. The analysis below is for the second page.

Title[redir]:
E-cadherin germline mutations in familial gastric cancer | Nature
Description:
The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cell–adhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a G→ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.

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Keywords {🔍}

cancer, article, google, scholar, cas, pubmed, ecadherin, gastric, nature, gene, mutations, access, human, cell, familial, zealand, content, cookies, diffuse, carcinoma, privacy, aotearoa, carcinomas, tumour, research, analysis, data, journal, guilford, hopkins, mcleod, clinical, genetic, linkage, expression, cells, invasion, open, dna, ads, central, res, advertising, information, subscribe, germline, parry, harraway, molecular, families,

Topics {✒️}

nature portfolio permissions reprints health research council privacy policy calcium-induced e-cadherin rigidification advertising e-cadherin invasion-suppressor gene social media subscribe nature nature genet author information authors nature 380 nature 392 nature e-cadherin gene revealed called intestinal-type carcinoma e-cadherin/catenin complex e-cadherin gene mutations e-cadherin germline mutations diminished e-cadherin expression microwave-based dna extraction author correspondence β catenin-tcf signalling personal data early-onset gastric cancer springerlink instant access histo-clinical classification data protection early invasion mediated permissions e-cadherin gene e-cadherin mutations e-cadherin expression cadherin gene superfamily human gynaecologic cancers privacy diffuse gastric cancer4 multilocus linkage analysis invasion suppressor role human genome based familial gastric cancer epithelial tumour cells7 gastric cancer remains truncated gene product myosin-viia gene poor clinical outcome human carinoma cells human genome database primary gastric carcinomas histological main types

Schema {🗺️}

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         headline:E-cadherin germline mutations in familial gastric cancer
         description:The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cell–adhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a G→ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.
         datePublished:
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      headline:E-cadherin germline mutations in familial gastric cancer
      description:The identification of genes predisposing to familial cancer is an essential step towards understanding the molecular events underlying tumorigenesis and is critical for the clinical management of affected families. Despite a declining incidence, gastric cancer remains a major cause of cancer death worldwide1, and about 10% of cases show familial clustering2,3. The relative contributions of inherited susceptibility and environmental effects to familial gastric cancer are poorly understood because little is known of the genetic events that predispose to gastric cancer. Here we describe the identification of the gene responsible for early-onset, histologically poorly differentiated, high grade, diffuse gastric cancer4 in a large kindred from New Zealand (Aotearoa). Genetic linkage analysis demonstrated significant linkage to markers flanking the gene for the calcium-dependent cell–adhesion protein E-cadherin. Sequencing of the E-cadherin gene revealed a G→ T nucleotide substitution in the donor splice consensus sequence of exon 7, leading to a truncated gene product. Diminished E-cadherin expression is associated with aggressive, poorly differentiated carcinomas5. Underexpression of E-cadherin is a prognostic marker of poor clinical outcome in many tumour types6, and restored expression of E-cadherin in tumour models can suppress the invasiveness of epithelial tumour cells7,8. The role of E-cadherin in gastric cancer susceptibility was confirmed by identifying inactivating mutations in other gastric cancer families. In one family, a frameshift mutation was identified in exon 15, and in a second family a premature stop codon interrupted exon 13. These results describe, to our knowledge for the first time, a molecular basis for familial gastric cancer, and confirm the important role of E-cadherin mutations in cancer.
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