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Title[redir]:
Targeting minimal residual disease: a path to cure? - PMC
Description:
Therapeutics that block kinases, transcriptional modifiers, immune checkpoints and other biological vulnerabilities are transforming cancer treatment. As a result, many patients achieve dramatic responses, including complete radiographic or ...
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Keywords {๐}
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Topics {โ๏ธ}
single-cell rna-seq supports transcriptomics single-cell rna-seq net pro-apoptotic signalling cell-free nucleic acids circulating-free tumor dna bcrโabl fusion kinase48 intraductal papillary-mucinous tumors df/koch bridge program oncogene withdrawal-induced apoptosis dynamic bh3 profiling single-cell mass accumulation single-cell rna-seq empowering single-cell โomics pmc beta search live-cell downstream assays alk-rearranged lung adenocarcinoma precede longer-term phenotypes dana-farber cancer institute small-cell lung cancer low-cost rna sequencing single-cell rna sequencing guide therapy decision-making cell free dna muscle-invasive bladder cancer long-term therapeutic pressure egfr-mutated lung cancer opinion article argues single-cell transcriptomics applied fixable bh3 profiling assay quantifies treatment-induced drug-free holidays measure single-cell response bcrโabl transcript mass accumulation rate patient-derived tumour xenografts nucleic acid-based biomarkers single-cell growth rates t-cell receptor relapse free survival pre-enrichment based flow cytometry-based dbp marker-free isolation real-time deformability cytometry minimal residual disease egfr-mutant nsclc patients tyrosine kinase inhibitors cancer precision medicine sc-rna-seq early immunophenotypic evaluation nucleic acids derived
Questions {โ}
- Bruggemann M, Raff T & Kneba M Has MRD monitoring superseded other prognostic factors in adult ALL?
- Martin OA, Anderson RL, Narayan K & MacManus MP Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?
- Ossenkoppele G & Schuurhuis GJ MRD in AML: does it already guide therapy decision-making?
- Targeting minimal residual disease: a path to cure?
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