
NCBI . NLM . NIH . GOV {
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Title[redir]:
Phase I/II trial of enzalutamide and mifepristone, a glucocorticoid receptor antagonist, for metastatic castration-resistant prostate cancer - PMC
Description:
Although androgen deprivation therapy (ADT) and androgen receptor signaling inhibitors (ARSI) are effective in metastatic prostate cancer (PC), resistance occurs in most patients. This phase I/II trial assessed the safety, pharmacokinetic impact, ...
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Keywords {🔍}
enz, mif, patients, cancer, psa, phase, study, google, scholar, prostate, doi, pubmed, dose, receptor, progression, pmc, enzmif, androgen, free, week, article, enzalutamide, clinical, combination, ctcs, arm, trial, randomization, time, weeks, expression, crpc, day, pfs, figure, glucocorticoid, randomized, levels, group, therapy, grade, analysis, mifepristone, daily, ctc, dosing, resistance, survival, studies, combined,
Topics {✒️}
abdominal/pelvic cross-sectional imaging neo-adjuvant castrate-sensitive stage castration-sensitive prostate cancer castration-resistant prostate cancer high-throughput florescence microscopy median progression-free survival enz-mif drug-drug interactions androgen-independent prostate cancer castrate-resistant prostate cancer pre-planned dose combinations line castration-sensitive setting pmc beta search androgen-receptor signaling axis ligand-independent ar activation pre-operative setting demonstrated study-drug-attributable grade 4 previous placebo-controlled trials cell-line cells spiked nuclear hormone activity long-term gr blockade absolute 5ng/ml increase dual ar-gr antagonism pre-randomization psa rr planned psa-progression events activate lbd-mutant ar advanced prostate cancer key secondary endpoints metastatic prostate cancer average post-randomization testosterone acknowledgements funding glucocorticoid receptor antagonist post-randomization time point castration-resistant pc prostate specific antigen phase ii endpoints defense cdmrp w81xwh-14-1-0021 androgen receptor blockade post-randomization analysis due adrenocorticotropic hormone leading trough drug concentration post-treatment psa increase human prostate cancer combination ar/gr inhibition glucocorticoid/progesterone antagonist [google scholar] 31 [google scholar] 34 [google scholar] 35 [google scholar] 36 [google scholar] 49 mol cancer ther
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- How much cash flow does https://doi.org/10.1126/scitranslmed.aac7531 have monthly?
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Science%20translational%20medicine&title=Targeting%20the%20glucocorticoid%20receptor%20in%20breast%20and%20prostate%20cancers&author=J%20Kach&author=SD%20Conzen&author=RZ%20Szmulewitz&volume=7&issue=305&publication_year=2015&pages=305ps319-305ps319&pmid=26378243&doi=10.1126/scitranslmed.aac7531&
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- How much does https://www.usa.gov/ net monthly?
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