
PMC . NCBI . NLM . NIH . GOV {
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Title:
The mitochondrial permeability transition pore: a mystery solved? - PMC
Description:
The permeability transition (PT) denotes an increase of the mitochondrial inner membrane permeability to solutes with molecular masses up to about 1500 Da. It is presumed to be mediated by opening of a channel, the permeability transition pore ...
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27 years and 8 months (reg. 1997-10-02).
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Keywords {🔍}
pubmed, google, scholar, doi, mitochondrial, permeability, ptp, transition, mitochondria, pmc, free, article, pore, membrane, biol, bernardi, cell, chem, atp, synthase, biophys, channel, cypd, complex, petronilli, csa, binding, cyclophilin, acta, biochem, death, biochim, opening, dimers, outer, effect, giorgio, calcium, inhibition, release, apoptosis, nature, cyclosporin, formation, matrix, swelling, role, liver, activity, proteins,
Topics {✒️}
peptidyl-prolyl cis-trans isomerase peptidyl-prolyl cis-trans-isomerase water-free chloroform extraction membrane-bound proton-translocating fo ion-conducting channels similar pmc beta search voltage-dependent anion channels salt-tolerant brine shrimp strain-matched wild-type mitochondria cyclosporin a-sensitive channel potentiates chemotherapy-induced cytotoxicity corona-de-la-peña anti-lymphocytic peptide cyclosporin ca2+-induced permeability transition reversible ca2+-induced permeabilization yeast f1fo-atp synthase voltage-dependent ion channel f1fo-atpase inhibitor protein full-length bid dimers bind mg2+-adp/atp ca2+-dependent membrane permeabilization apoptosis protein-caspase interaction anion-selective channel function form ca2+-activated channels cell-free extracts ca2+-induced membrane transition ca2+-activated mitochondrial pores peripheral-type benzodiazepine receptors mitochondrial-dependent cell death mt-cpyfp flash activity benzodiazepine-induced superoxide signals ca2+-dependent pt occurs peripheral-type benzodiazepine receptor calcium ion-induced swelling el mir long-sought molecular trigger ubiquinone-binding site regulates potential s-nitrosylation sites atp-hydrolyzing mitochondria required cypd-expressing mitochondria respond pore open-closed probability questionable pathophysiological relevance apoptosis-inducing agent acting hematoporphyrin-mediated photooxidative stress fof1 atp synthase mg2+-prevented ca2+ release ca2+-dependent cell survival channel-forming proteins suggested mitochondrial unselective channels wei-lapierre
Questions {❓}
- Characterization of the yeast mitochondria unselective channel: a counterpart to the mammalian permeability transition pore?
- Is p53 the long-sought molecular trigger for cyclophilin D-regulated mitochondrial permeability transition pore formation and necrosis?
- Mechanisms of apoptosis in Crustacea: what conditions induce versus suppress cell death?
- Mitochondrial permeability transitions: how many doors to the house?
- Mitochondrial permeability: dual role for the ADP/ATP translocator?
- Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function?
- The mitochondrial permeability transition pore: a mystery solved?
- The permeability transition and BCL-2 family proteins in apoptosis: co-conspirators or independent agents?
- What is the nature of the mitochondrial permeability transition pore and what is it not?
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