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Title:
Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations - PubMed
Description:
We have studied the induction of the mitochondrial cyclosporin A-sensitive permeability transition pore (PTP) by the bifunctional SH group reagent phenylarsine oxide (PhAsO). Addition of nanomolar concentrations of the electroneutral H(+)-K+ ionophore nigericin to nonrespiring mitochondria in sucros …
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Keywords {🔍}
pmid, mitochondrial, permeability, transition, pore, induction, ptp, mitochondria, doi, bernardi, pharmacology, divalent, cations, free, article, nigericin, pmc, similar, articles, cited, mesh, biol, chem, zoratti, cyclosporin, phaso, main, ncbi, related, resources, modulation, effect, szabó, asensitive, phenylarsine, oxide, matrix, process, azzone, bioenerg, biomembr, megachannel, pubmed, membrane, review, effects, hhs, page, content, homepage,
Topics {✒️}
main page content similar articles cited early effects ion specificity divalent cations ischemia/reperfusion cardiac injury rat liver mitochondria respiration-inhibited mitochondria literature sources nonrespiring mitochondria mitochondria loaded yeast mitochondria + ionophore nigericin mesh keyword ionophore-induced acidification united states government patch-clamp experiments open-closed orientation biochim biophys acta antineoplastic agent salinomycin books pubchem compound similar results sucrose medium determines proton electrochemical gradient cell death dis matrix ph indicators nigericin resources phenylarsine oxide mitochondrial membrane directly related cited ptp induction process pore induction mitochondrial megachannel mitochondrial function membrane depolarization cyclosporin cell death pubmed wordmark pubmed logo transition matrix ph hhs kcl medium proton flow official website nanomolar concentrations dramatic increase time required
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