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Title:
Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D - PubMed
Description:
We have studied the properties of the permeability transition pore (PTP) in mitochondria from the liver of mice where the Ppif gene encoding for mitochondrial Cyclophilin D (CyP-D) had been inactivated. Mitochondria from Ppif-/- mice had no CyP-D and displayed a striking desensitization of the PTP t …
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Keywords {🔍}
doi, pmid, mitochondria, mitochondrial, permeability, cyclophilin, transition, pore, free, article, ptp, mice, pmc, cypd, epub, metabolism, similar, articles, mesh, biol, chem, ppif, calcium, research, chemistry, main, ncbi, cited, resources, jbcc, mar, basso, forte, bernardi, liver, gene, wildtype, pubmed, aug, review, physiol, nih, cyclophilins, oxygen, protein, pubchem, hhs, page, content, states,
Topics {✒️}
main page content mitochondrial calcium uniporter mir-30b-5p/camkii pathway similar articles cited inbred c57bl mice mesh keyword wild-type mice united states government extramural research support ppif-/- mice liver pubchem substance grants ppif gene encoding oxidative stress mitochondrial permeability transition mice permeability transition pore funding linkout mitochondrial apoptotic signalling biomedical research pore opening required resources proton electrochemical gradient promoting regulated necrosis kidney proximal tubules curr med chem ca2+ retention capacity 17127624 genetic dissection ca2+-induced damage cell death dis mol membr biol physiol renal physiol wild-type mitochondria cited mitochondria lacking cyp similar hhs mitochondrial cyclophilin wild-type cell death pubmed wordmark pubmed logo biol chem ubiquinone 0 mol sci mitochondria devoid brain mitochondria official website lisa fante jonathan fowlkes
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