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Title:
Switch from inhibition to activation of the mitochondrial permeability transition during hematoporphyrin-mediated photooxidative stress. Unmasking pore-regulating external thiols - PubMed
Description:
We have studied the mitochondrial permeability transition pore (PTP) under oxidizing conditions with mitochondria-bound hematoporphyrin, which generates reactive oxygen species (mainly singlet oxygen, (1)O(2)) upon UV/visible light-irradiation and promotes the photooxidative modification of vicinal …
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Keywords {🔍}
mitochondrial, permeability, doi, transition, pmid, epub, free, pore, article, pmc, bernardi, oxygen, metabolism, articles, mesh, stress, ricchelli, hematoporphyrin, singlet, cysteines, cell, review, main, ncbi, similar, cited, resources, biophys, jbbabio, apr, photooxidative, external, ptp, vicinal, site, nature, light, pubmed, sep, atp, calcium, transport, membrane, compounds, pharmacology, hhs, page, content, homepage, navigation,
Topics {✒️}
mitochondrial calcium transport singlet oxygen produced singlet oxygen main page content mitochondrial permeability transition reactive oxygen/nitrogen species similar articles cited drug dose-response relationship membrane-impermeant reagents oxidative stress hematoporphyrin-mediated photooxidative stress oligomycin-sensitivity conferring protein induced mitochondrial swelling uv/visible light-irradiation de souza-pinto nc mitochondrial atp synthase pore domains oxidation mitochondrial pathophysiology mitochondria-bound hematoporphyrin biochim biophys acta mesh keyword ptp-regulating cysteines pore biochem cell biol de oliveira hcf arch biochem biophys external cysteines promoted united states government federica dabbeni-sala photoresistant site coincides solanum anguivi lam vitro antioxidant properties sensitizer/light doses mol cell cardiol vicinal hematoporphyrin reactivates ptp-modulating properties cited 11829534 shedding light photooxidative modification vicinal hematoporphyrin cell death hhs pubmed wordmark pubmed logo cysteines sensitive mol sci atp synthase linkout vicinal targets
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- The mitochondrial permeability transition pore: a mystery solved?
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