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Title:
Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore - PubMed
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The mitochondrial permeability transition pore (MPTP) plays a key role in cell death, especially necrosis, and mediates the injury tissues such as the heart and brain experience following ischaemia and reperfusion. However, the molecular identity of the MPTP remains uncertain. Knockout studies have …
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Keywords {🔍}
mitochondrial, doi, pore, permeability, pmid, transition, role, review, epub, halestrap, free, article, cell, pmc, mptp, heart, membrane, similar, articles, opening, ant, pic, physiology, main, ncbi, cited, mesh, resources, molecular, key, death, component, pubmed, aug, apr, transport, proteins, foundationunited, kingdom, hhs, page, content, homepage, navigation, search, full, text, abstract, publication, types,
Topics {✒️}
atp translocases grants permeability transition pore aldose reductase-mediated phosphorylation mitochondrial phosphate carrier main page content funding linkout membrane component membrane protein united states government permeability transition similar articles cited mitochondrial dysfunction necrosis 23625488 physiology induces pore opening modulate pore opening heart transmembrane pore component calcium-triggered conformational change biochim biophys acta similar knockout studies pore opening cell death mol cell cardiol yeast mitochondria adenine nucleotide translocase curr med chem scale-free flow antioxid redox signal mptp remains uncertain summarise recent evidence cited conformational change biol chem knockout studies calcium signaling cell hhs pubmed wordmark pubmed logo recent progress transmembrane channel halestrap ap central component mptp opening official website molecular mechanism injury tissues molecular identity cast doubt
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- What is the mitochondrial permeability transition pore?
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