
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation - PubMed
Description:
The immunosuppressive drugs cyclosporin A (CsA) and FK506 both interfere with a Ca(2+)-sensitive T-cell signal transduction pathway, thereby preventing the activation of specific transcription factors (such as NF-AT and NF-IL2A) involved in lymphokine gene expression. CsA and FK506 seem to act by in …
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Keywords {🔍}
calcineurin, pmid, doi, proteins, tacrolimus, metabolism, activation, pmc, articles, mesh, nature, cyclosporin, tcell, signal, transduction, transcription, nfat, interaction, biol, epub, free, article, main, ncbi, abstract, similar, cited, resources, jun, csa, gene, receptors, review, effects, support, immunosuppression, pubmed, interleukin, yang, cell, research, calmodulinbinding, genetics, phosphoprotein, phosphatases, hhs, page, content, homepage, navigation,
Topics {✒️}
ca2+/calmodulin-regulated phosphatase calcineurin t-lymphocyte activation lymphokine gene expression main page content interleukin-2 promoter similar articles cited altered metabolism signal transduction tacrolimus cell death dis tumor cell invasion cognate intracellular receptors lymphocytes resistant mesh keyword csa-sensitive activation inhibit calcineurin activity literature sources calcineurin-mediated insulin provide biological evidence results identify calcineurin resources nature transcription factor creb drug-isomerase complexes specific transcription factors nfil2a-dependent transcription csa/fk506-mediated immunosuppression united states government o'keefe sj o'neill ea kb control element signaling cross-talks mitochondrial respiratory stress jurkat cells renders 1038/357695a0 abstract key signalling enzyme immunosuppressive drugs cyclosporin polyomavirus jc regulation calcineurin underlies research support activation 12644894 activation cited abstract calcineurin pubmed wordmark pubmed logo ca2+ signals key enzyme mol pharmacol crabtree gr
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