
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death - PubMed
Description:
Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition (mPT) leads to mitochondrial swelling, outer membrane rupture and the release of apoptotic mediators. The mPT pore is thought to consist of the adenine nucleotide transloc …
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Keywords {🔍}
cell, death, mitochondrial, doi, pmid, cyclophilin, mice, permeability, transition, pmc, protein, metabolism, nature, mitochondria, ppif, epub, free, article, gene, cited, swelling, proteins, articles, mesh, null, oxidative, review, drug, calcium, cardiac, research, cyclophilins, main, ncbi, abstract, similar, resources, mar, role, apoptotic, membrane, isomerase, protected, fibroblasts, pubmed, shimizu, tsujimoto, stress, sep, genetics,
Topics {✒️}
tumour-necrosis factor-alpha-induced death drug-induced liver injury protein atractyloside cytochromes ischaemia/reperfusion-induced cell death main page content mitochondrial-dependent cell death drug metab rev voltage-dependent anion channel calcium signaling protein protein mesh keyword books gene gene cell death christopher spontaneous cell death cell death mechanisms mice overexpressing cyclophilin necrotic cell death apoptotic cell death mitochondrial swelling prolyl isomerase located resources nature ppif gene product ppif null mice mitochondrial permeability transition inhibiting oxidative stress cell death cardiac mitochondria ppif protein similar articles cited ppif null fibroblasts improving mitochondrial dysfunction nat cell biol mol cell cardiol research support mitochondria isolated outer membrane rupture united states government adenine nucleotide translocator focal cerebral ischemia biochim biophys acta medgen nucleotide omim biomedical research knockout mice mitochondria fibroblasts isolated mitochondrial matrix permeability transition cell rep abstract oxidant stress
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