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Title:
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia - PubMed
Description:
Mitochondrial permeability transition (PT) is a phenomenon induced by high levels of matrix calcium and is characterized by the opening of the PT pore (PTP). Activation of the PTP results in loss of mitochondrial membrane potential, expansion of the matrix, and rupture of the mitochondrial outer mem …
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Keywords {🔍}
cell, mitochondrial, doi, death, pmid, pubmed, permeability, cyclophilin, transition, metabolism, pmc, cypddeficient, nih, states, calcium, cypd, epub, brain, free, article, hhsunited, articles, cited, mesh, cerebral, ischemia, role, mouse, fig, nature, main, ncbi, similar, references, grants, resources, component, korsmeyer, induced, ptp, membrane, apoptotic, critical, mitochondria, susceptible, central, hydrogen, peroxide, mice, biol,
Topics {✒️}
united states government blair ns cypd-deficient mice displayed hydrogen peroxide hhs ischemia/reperfusion-mediated cell death apoptosis-related markers main page content pubmed show similar articles cited funding linkout global cerebral ischemia-reperfusion cypd-deficient mitochondria showed focal cerebral ischemia metabolism brain infarct size books gene gene cypd-deficient mouse articles references danial mitochondrial permeability transition apoptosis neonatal brain mesh keyword mitochondrial membrane potential mitochondrial outer membrane extramural research support literature sources retain calcium calcium overload permeability transition ischemic injury model matrix calcium central component specific death stimuli curr pharm des synaptic properties altered front syst neurosci cited cell death induced 27664163 mitochondrial dysfunction classical apoptotic stimuli medgen protein protein cypd-deficient mefs research support calcium apoptotic cell death necrotic cell death oxidative stress pubmed green pubmed orrenius
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