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Title:
Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3 - PubMed
Description:
Ethanol increases the vulnerability of mitochondria to induction of the mitochondrial permeability transition (MPT). Cyclophilin-D activity enhances the potential for the permeability transition pore (PTP) to open. In the present study, we demonstrate that ethanol and its metabolism sensitize the PT …
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Keywords {🔍}
doi, pmc, sirtuin, pmid, cell, article, ethanol, free, mitochondria, permeability, pubmed, transition, cyclophilind, cyclophilin, retraction, abstract, sci, jcs, epub, mitochondrial, activity, deacetylation, metabolism, acetylation, fig, mediated, shulga, pastorino, nih, expression, articles, mesh, inhibiting, pore, review, chem, biol, main, states, ncbi, authors, concern, figures, similar, cited, references, publication, information, grants, resources,
Topics {✒️}
united states government main page content resources retracted article funding linkout pubchem substance grants retraction notice alloxan-induced diabetic mice literature sources ethanol metabolism articles references ahn ethanol sensitizes mitochondria mesh keyword metabolism sensitize ethanol exposure stimulates ethanol-enhanced acetylation permeability transition pore hhs mitochondrial permeability transition lapachol-induced upregulation mol cell cardiol ethanol-induced suppression adenine nucleotide translocator-1 myocardial reperfusion injury biochim biophys acta post-translational modifications regulating energy homeostasis adenine nucleotide translocase-1 dominantly induce apoptosis similar articles cited mitochondrial aldehyde dehydrogenase cell death dis crola-da-silva sirtuin-3 nataly shulga 1 mitochondrial deacetylase sirt3 sirt3-mediated deacetylation curr med chem kupffer cell activation hexokinase ii binding ethanol exposure pubmed wordmark pubmed logo permeability transition mitochondria devoid cell sci doi abstract figures comment sirtuin activity sirtuin-3 activity inhibits glycolysis cell death sirtuin-3 prevented
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