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Title:
Inhibition of complex I regulates the mitochondrial permeability transition through a phosphate-sensitive inhibitory site masked by cyclophilin D - PubMed
Description:
Inhibition of the mitochondrial permeability transition pore (PTP) has proved to be an effective strategy for preventing oxidative stress-induced cell death, and the pore represents a viable cellular target for drugs. Here, we report that inhibition of complex I by rotenone is more effective at PTP β¦
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Keywords {π}
mitochondrial, doi, complex, pmid, permeability, transition, rotenone, pore, inhibition, cyclophilin, ptp, cyclosporin, epub, free, article, metformin, pmc, transport, similar, articles, cited, mesh, effects, mol, review, main, ncbi, resources, cell, tissues, expression, pubmed, physiology, pharmacology, electron, pubchem, hhs, page, content, homepage, navigation, search, full, text, abstract, publication, types, terms, substances, related,
Topics {βοΈ}
main page content similar articles cited mitochondrial permeability transition permeability transition pore related information cited books gene protein antidiabetic drug metformin stress-induced opening similar effect mol cell cardiol mitochondrial complex mesh keyword partially inhibits complex united states government compensated ventricular hypertrophy porter ga jr handb exp pharmacol ischemic brain injury future cardioprotective strategies mitochondrial target damien de paulis frΓ©dΓ©ric de oliveira viable cellular target express low levels pore represents mol membr biol pore modulation restored ptp inhibition ptp-inhibiting effects increased vulnerability metformin cited pubmed wordmark pubmed logo inhibitory effects mol sci hhs phosphate requirement high levels de marchi de palma ptp inhibition official website bo liΒ 1 christiane chauvin guillaume vial sandrine lablanche xavier leverve genetic ablation striking analogy
Questions {β}
- Modulation of the mitochondrial permeability transition by cyclophilin D: moving closer to F(0)-F(1) ATP synthase?
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