PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423 - PubMed
Description:
Bz-423 is a 1,4-benzodiazepine that suppresses disease in lupus-prone mice by selectively killing pathogenic lymphocytes, and it is less toxic compared to current lupus drugs. Cells exposed to Bz-423 rapidly generate O(2)(-) within mitochondria, and this reactive oxygen species is the signal initiat …
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Keywords {🔍}
doi, pmid, mitochondrial, drug, pmc, oscp, free, article, inhibitors, proteins, ffatpase, target, glick, mitochondria, synthase, articles, mesh, opipari, oligomycin, protein, epub, atp, oct, metabolism, antagonists, pharmacology, effects, main, ncbi, similar, cited, related, resources, chem, biol, apr, jchembiol, molecular, johnson, swenson, lymphocytes, lupus, cells, inhibition, rna, pubmed, aug, sci, nih, adenosine,
Topics {✒️}
oligomycin sensitivity-conferring protein main page content promising anti-lupus drug mitochondrial dysfunction-related diseases molecular drug evaluation mitochondrial atp synthase mitochondrial f1f0-atpase mitochondrial atp synthesis mesh keyword united states government reactive oxygen species resources chem biol literature sources pubchem substance grants mitochondrial megachannel resides proton conductance proton channel funding linkout extramural research support related polyphenols mitochondria bz-423 rapidly generate oligomycin axis reagents lupus erythematosus similar articles cited molecular target lupus-prone mice current lupus drugs signal initiating apoptosis reconstitution experiments demonstrated pharmacol exp ther permeability transition pore opipari aw jr rna interference acs chem biol bovine f1-atpase reduced oscp expression sensitivity potential therapeutic target bz-423 binds bz-423 inhibited mechanistic basis mitochondrial hhs therapeutic targeting opipari jr life sci chem biol f1fo-atpase lupus therapeutics
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