
PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction - PubMed
Description:
Cyclosporin A, the major immunosuppressive drug in transplantation, and the more potent therapeutic drug candidate, FK506, have led to the discovery of two superfamilies of immunosuppressant binding proteins, the cyclophilins and the FK binding proteins. These proteins, enzymes with high kcat values …
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Keywords {🔍}
pmid, protein, free, article, proteins, doi, pmc, cell, signal, transduction, cyclophilin, isomerases, articles, mesh, review, biol, cyclosporin, peptidylprolyl, calcineurin, metabolism, main, states, ncbi, search, similar, cited, resources, binding, folding, roles, drugimmunophilin, complex, molecular, pubmed, isomerase, amino, acid, carrier, nih, hhs, page, content, homepage, navigation, full, text, actions, abstract, publication, types,
Topics {✒️}
peptidylprolyl isomerases peptidyl-prolyl cis-trans isomerase 7520696 proline isomerases cell activation fk binding proteins immunosuppressant binding proteins united states government main page content 90kd proteins signal transduction cascade cell signal transduction proteins similar articles cited protein phosphatase 2b signal transduction resources review mesh keyword protein substrates protein folding protein trafficking 20kd protein funding linkout u4/u6-specific 60kd 1515410 review 7529736 review molecular insights gained specific downstream target human [u4/u6 drug-immunophilin complexes hhs high kcat values x-pro bonds play major roles potent pseudosubstrate ligands actions u5] tri-snrnps tcr/cd3-stimulated major immunosuppressive drug drug-immunophilin complex leishmania tropica complex mol cell biol molecular analysis cited research support walkinshaw md search pubmed wordmark pubmed logo cell compartments immunosuppressant drugs
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