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Title:
Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes - PubMed
Description:
Exchangeable intracellular Ca2+ as measured by 45Ca2+ uptake more than doubled when isolated adult rat ventricular cardiomyocytes were incubated 30 min with 8 microM cyclosporin; nevertheless the cells retained a normal rod-shaped morphology. High concentrations of ouabain caused a similar increase …
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Keywords {🔍}
mitochondrial, pmid, doi, cyclosporin, calcium, pore, permeability, cells, pmc, metabolism, similar, articles, mesh, physiol, adult, rat, ventricular, cardiomyocytes, uptake, microm, ruthenium, red, sep, transition, epub, cell, review, free, article, main, ncbi, cited, resources, efflux, isolated, concentration, heart, pubmed, mitochondria, hhs, page, content, states, homepage, navigation, search, full, text, abstract, publication,
Topics {✒️}
ruthenium red sarcoplasmic reticulum main page content similar articles cited mitochondrial calcium exchange mol cell biochem physiol cell physiol united states government normal rod-shaped morphology concentration dependent cyclophilin d-dependent manner mesh keyword single rat cardiomyocytes permeability transition pore calcium resources funding linkout mitochondrial cyclophilin inhibits periodic transient increases cat ventricular myocytes net 45ca2+ accumulation membrane permeability provide mitochondrial ca2+ extrusion increases mitochondrial buffering mitochondrial 45ca2+ efflux similar increase round disorganized form ca2+ overload caused ischaemia/reperfusion injury cyclosporin-sensitive mitochondrial mitochondria cited mitochondrial ca2+ membrane pore hhs 45ca2+ efflux pubmed wordmark pubmed logo ca2+ signaling normal conditions brierley gp free media mitochondrial ca ouabain caused prelabeled myocytes simulated reperfusion grants 45ca2+ uptake cells retained physiol rev
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