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Title:
Imaging the permeability pore transition in single mitochondria - PubMed
Description:
In mitochondria the opening of a large proteinaceous pore, the "mitochondrial permeability transition pore" (MTP), is known to occur under conditions of oxidative stress and matrix calcium overload. MTP opening and the resulting cellular energy deprivation have been implicated in processes such as h …
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Keywords {🔍}
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Topics {✒️}
main page content similar articles cited light-induced generation matrix calcium overload voltage-sensitive fluorescent dye low-conductance channel repetitive gating literature sources cyclosporin-sensitive pore calcium signaling permeability transition pore permeability pore transition mesh keyword mitochondrial membrane induced large membrane pore resources biophys vitro membrane permeability mtp inhibitor cyclosporin large proteinaceous pore mitochondrial populations revealed united states government 77920-2 abstract causing marked oscillations matrix-entrapped calcein repeated stochastic openings melik-nubarov ns arch biochem biophys hypoxic cell damage physiol cell physiol biochim biophys acta mitochondrial membrane environ health perspect repetitive transient depolarizations membrane potential increased permeability transition pore cited research support pubmed wordmark pubmed logo single mitochondria oxidative stress mitochondrial populations individual mitochondria mitochondrial channelopathies voltage decay biol chem delta psi blatter la
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