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Title:
The permeability transition pore as a mitochondrial calcium release channel: a critical appraisal - PubMed
Description:
Mitochondria from a variety of sources possess an inner membrane channel, the permeability transition pore. The pore is a voltage-dependent channel, activated by matrix Ca2+ and inhibited by matrix H+, which can be blocked by cyclosporin A, presumably after binding to mitochondrial cyclophilin. The β¦
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Keywords {π}
mitochondrial, doi, permeability, pore, pmid, transition, channel, pubmed, release, review, apr, calcium, pmc, articles, mitochondria, function, free, article, metabolism, main, ncbi, similar, cited, references, mesh, resources, bioenerg, biomembr, bernardi, membrane, cell, biophys, regulation, hhs, page, content, states, homepage, navigation, search, abstract, publication, types, terms, substances, linkout, petronilli, sources, voltagedependent, matrix,
Topics {βοΈ}
main page content similar articles cited permeability transition pore calcium-homeostasis mitochondrial permeability transition resources review voltage-dependent channel calcium signaling selective release channel induced ros release cellular ca2+ homeostasis high-conductance state merlavs'kyΔ vm man'ko vv direct postconditioning effect ischemia reperfusion injury perez-pol jr phenomenon accompanying induction ischemia-reperfusion injury biochim biophys acta united states government rat isolated hearts reactive oxygen species cyclosporin-sensitive pore mitochondria membrane channel sources possess cited 9132412 review 7896766 review 11519724 review endothelial cells matrix ca2+ mitochondrial cyclophilin mitochondrial membrane mitochondrial uniporter hhs pubmed wordmark pubmed logo mitochondrial function transported species open states rat brain cell viability cell death official website bioenerg biomembr critical appraisal experimental reasons striking analogies
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