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Title:
Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor - PubMed
Description:
Although PK11195 binds to the peripheral benzodiazepine receptor with nanomolar affinity, significant data exist which suggest that it has another cellular target distinct from the PBR. Here we demonstrate that PK11195 inhibits F(1)F(0)-ATPase activity in an OSCP-dependent manner, similar to the pro …
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Keywords {🔍}
doi, pmid, mitochondrial, pmc, receptor, apoptosis, cell, free, article, similar, articles, mesh, ffatpase, ligands, benzodiazepine, induction, jul, review, pubchem, main, ncbi, abstract, cited, resources, chem, jbmcl, epub, peripheral, target, pubmed, atp, effects, cells, antineoplastic, nih, metabolism, antagonists, hhs, page, content, states, homepage, navigation, search, full, text, publication, types, terms, substances,
Topics {✒️}
main page content pubchem substance grants similar articles cited antineoplastic agent erucylphosphohomocholine rat liver mitochondria peripheral benzodiazepine receptor peripheral benzodiazepin receptor pro-apoptotic benzodiazepine bz-423 united states government tspo ligands atpase activity glioblastoma cell lines mesh keyword biochem cell biol mol cell cardiol funding linkout ligands mitochondrial f1f0-atpase immunomodulatory benzodiazepine bz-423 apoptosis induction independently oscp-dependent manner cellular responses observed gonzalez-polo ra biochem soc trans reactive oxygen species le van kim significant data exist cellular target distinct opipari aw jr effects cited similar apoptosis induction 102 abstract abstract chem biol pk11195 inhibits hhs f0f1-atp atp release opipari jr glick gd pubmed wordmark pubmed logo human services atpase inhibition apoptosis mol sci official website nanomolar affinity
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