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Title:
Singlet oxygen produced by photodynamic action causes inactivation of the mitochondrial permeability transition pore - PubMed
Description:
We have studied the effects of singlet oxygen produced by photodynamic action on the cyclosporin A-sensitive permeability transition (PT) in isolated rat liver mitochondria. Mitochondria were incubated with 3 microM hematoporphyrin and irradiated at 365 nm with a fluence rate of 25 watts/m2. For sho β¦
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Keywords {π}
doi, pore, pmid, permeability, transition, mitochondria, oxygen, photodynamic, action, mitochondrial, bernardi, singlet, free, article, effects, pmc, articles, mesh, diethyl, pyrocarbonate, diamide, petronilli, biophys, channels, main, ncbi, similar, cited, resources, biol, chem, jbc, produced, salet, liver, histidine, dithiol, modulation, pubmed, voltagedependent, apr, membrane, metabolism, pharmacology, hhs, page, content, homepage, navigation, search,
Topics {βοΈ}
voltage-dependent induction singlet oxygen produced diethyl pyrocarbonate membrane photopotential generation main page content similar articles cited resources mesh keyword pore open-closed probability diamide hematoporphyrin-loaded mitochondria treated permeability transition pore permeability pore transition oxidative effects hematoporphyrin-loaded mitochondria effects united states government adenine nucleotide translocase proton electrochemical gradient redox-cycling naphthoquinones toxicol appl pharmacol physico-chemical determinants hematoporphyrin-derivative photosensitization reversible histidine protonation site-selective inactivation critical dithiol involved arch biochem biophys cited mitochondria retained single mitochondria pore denaturation pubmed wordmark pubmed logo pt pore pore modulation mitochondria hhs photodynamic action 3 microm hematoporphyrin critical histidines linkout histidine reagent dithiol cysteines dithiol oxidation unique histidine photodynamic reaction official website 25 watts/m2 short durations thiol oxidant
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