PUBMED . NCBI . NLM . NIH . GOV {
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Title:
Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice - PubMed
Description:
Cyclophilin D (which is encoded by the Ppif gene) is a mitochondrial matrix peptidyl-prolyl isomerase known to modulate opening of the mitochondrial permeability transition pore (MPTP). Apart from regulating necrotic cell death, the physiologic function of the MPTP is largely unknown. Here we have s …
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Keywords {🔍}
doi, mitochondrial, mice, pmid, ppif, permeability, transition, cyclophilin, pmc, pubmed, heart, epub, pore, cell, death, free, article, review, states, figure, nature, nih, display, articles, mesh, mptp, function, metabolism, hlhlnhlbi, hhsunited, main, ncbi, similar, cited, references, related, information, grants, resources, failure, molkentin, gene, matrix, peptidylprolyl, isomerase, physiologic, hypertrophy, myocardial, stimulation, increased,
Topics {✒️}
united states government substances peptidyl-prolyl isomerase main page content hhs similar articles cited funding linkout mitochondrial transport systems mitochondrial membrane permeabilization permeability transition pore mitochondrial permeability transition articles references kroemer cardiomyocyte-specific transgene expression radiation-induced heart disease cardiac-restricted transgenic rescue mptp-mediated ca match metabolism mesh keyword literature sources mitochondrial matrix ca heart failure mitochondrial atp synthase bcl-2 proteins extramural research support ppif gene elevated matrix ca joan heller brown pressure overload stimulation sustained exercise stimulation acta pharmacol sin biochim biophys acta radiation-induced alterations focal cerebral ischemia calcium aging heart disease apoptotic cell death myocardial function myocardial workload oxidative stress caused rat heart health mice john control mice mice rescued resources cited mitochondrial dysfunction mitochondrial swelling dependent dehydrogenases enhanced hypertrophy
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