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We are analyzing https://www.nature.com/articles/s41580-020-00324-8.

Title:
Ferroptosis: mechanisms, biology and role in disease | Nature Reviews Molecular Cell Biology
Description:
The research field of ferroptosis has seen exponential growth over the past few years, since the term was coined in 2012. This unique modality of cell death, driven by iron-dependent phospholipid peroxidation, is regulated by multiple cellular metabolic pathways, including redox homeostasis, iron handling, mitochondrial activity and metabolism of amino acids, lipids and sugars, in addition to various signalling pathways relevant to disease. Numerous organ injuries and degenerative pathologies are driven by ferroptosis. Intriguingly, therapy-resistant cancer cells, particularly those in the mesenchymal state and prone to metastasis, are exquisitely vulnerable to ferroptosis. As such, pharmacological modulation of ferroptosis, via both its induction and its inhibition, holds great potential for the treatment of drug-resistant cancers, ischaemic organ injuries and other degenerative diseases linked to extensive lipid peroxidation. In this Review, we provide a critical analysis of the current molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of ferroptosis in tumour suppression and immune surveillance, and its pathological roles, together with a potential for therapeutic targeting. Importantly, as in all rapidly evolving research areas, challenges exist due to misconceptions and inappropriate experimental methods. This Review also aims to address these issues and to provide practical guidelines for enhancing reproducibility and reliability in studies of ferroptosis. Finally, we discuss important concepts and pressing questions that should be the focus of future ferroptosis research. Ferroptosis is a form of regulated cell death driven by iron-dependent phospholipid peroxidation. Since its formal identification in 2012, multiple studies have addressed molecular mechanisms, regulation and functions of ferroptosis, associating this cell death modality with various pathologies, but also proposing its roles in normal physiology and potential for therapeutic targeting.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

pubmed, google, scholar, cas, cell, ferroptosis, central, death, cancer, biol, cells, chem, nature, paper, iron, reports, nat, glutathione, lipid, gpx, pathway, peroxidase, article, disease, peroxidation, sci, role, access, tumor, protein, mechanisms, research, tumour, development, induces, res, molecular, biology, conrad, redox, form, expression, usa, oxidative, ferroptotic, mol, oxygen, metabolic, activity, suppression,

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permissions reprints nature portfolio journals privacy policy nature portfolio author information authors rna-binding protein elavl1/hur regional development advertising p62–keap1–nrf2 pathway protects apoptosis-inducing factor-homologous mitochondrion social media cystine/glutamate transporter-deficient mice cell death research cystine/glutamate antiporter xct p53-dependent apoptotic cells open issues european research council future ferroptosis research gch1–bh4-dependent pathway p53-inducible apoptogenic gene iron-dependent phospholipid peroxidation prevent hydroperoxide-induced ferroptosis caveolin-1/β-catenin pathway induces caspase-independent apoptosis glutathione-independent ferroptosis suppressor meg3/mir-214/aifm2 axis cysteine deprivation-induced ferroptosis carbon-centred lipid radicals rice–magnaporthe oryzae interactions produces terpene-derived compounds endoplasmic reticulum stress t-cell lymphoblastic lymphoma glutamate receptor-expressing neurons pparα-mediated lipid remodeling masked nitrile-oxide electrophiles neuronal cell death elicited genotype-selective antitumor agents fluorescence-enabled inhibited autoxidation cancer-acquired drug resistance gambogic acid-iron nanozymes p53-mediated tumour suppression cystine transporter xct mitochondrial apoptosis-inducing factor suppressing pparα-mediated induction personal data research field horizon 2020 research nature+ nature 447 nature 184

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