
NCBI . NLM . NIH . GOV {
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Title[redir]:
On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death - PMC
Description:
Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation of lipid hydroperoxides that may play a key role in the pathogenesis of degenerative diseases in which lipid peroxidation has been implicated. ...
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Keywords {π}
lip, fer, doi, google, scholar, ferroptosis, pubmed, cell, Ξ±toh, lipid, cells, radicals, peroxyl, chem, inhibition, pmhc, inhibited, pmc, inhibitors, thns, antioxidants, lox, determined, free, gpx, figure, peroxidation, article, autoxidation, reaction, death, reactivity, radicaltrapping, autoxidations, rate, activity, radical, data, bilayers, results, cthn, pratt, information, reactive, effective, kinh, potent, inhibitor, similar, supporting,
Topics {βοΈ}
n-t-butyl-4-t-butylaniline diffusion-controlled chain-breaking antioxidants cystine/glutamate transporter-deficient mice experimental methods materials tamoxifen-induced cre-mediated deletion 6-di-tert-butyl-4-methylphenol p53-mediated ferroptotic responses [doi] [google scholar] cral-trio protein family h-bond accepting entities enzyme-mediated processes catalyzed o-quinone diimide intermediate pmc beta search weaker h-bond donors characteristic ms/ms transitions high-throughput screening efforts aif-mediated cell death short abstract esi-uplc/ms/ms recombinant pcdna3/15-lox-1 construct65 poorer h-bond donors trapping chain-carrying radicals hydroperoxide-detoxifying enzyme gpx4 h-bond accepting media excellent radical-trapping antioxidants stronger h-bonding interactions weaker h-bonding interactions increased radical-trapping capacity radical-trapping antioxidant chemistry premier lipid-soluble rta chain-carrying peroxyl radicals lipoxygenase-catalyzed lipid peroxidation diarylamine radical-trapping antioxidants aminic radical-trapping antioxidants rsl-3-induced cell death free radical peroxidation low steady-state concentration good radical-trapping antioxidants initial h-atom transfer higher steady-state concentration phenolic h-atom transfer free radical oxidation o-quinone diimide wild-type hek293 cells h-atom transfer reaction radical-trapping antioxidant activity chain-breaking antioxidants polyunsaturated fatty acids tissue Ξ±-tocopherol concentrations pfa-1 mouse fibroblasts
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