
NCBI . NLM . NIH . GOV {
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Title[redir]:
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway - PMC
Description:
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness1–4. A high-mesenchymal cell state observed in human tumours and cancer cell lines has been associated ...
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Keywords {🔍}
cells, cell, gpx, cancer, doi, mesenchymal, data, fig, lines, state, compounds, sensitivity, pubmed, google, scholar, pmc, extended, article, free, lipid, inhibition, correlation, inhibitor, compound, levels, medium, resistance, zeb, cellline, treatment, therapyresistant, highmesenchymal, death, expression, statetargeting, rsl, replicates, melanoma, plotted, protein, ferrostatin, dependency, figure, line, experiments, cellular, supplementary, gene, epithelial, open,
Topics {✒️}
inhibit 3-hydroxy-3-methyl-glutaryl-coa reductase mcf-7 er-snail1 cells20 epithelium-derived cancer lineages zeb1-targeting crispr-cas9 technology serum-free hpgm medium mesenchymal state-targeting properties therapy-resistant mesenchymal state high-mesenchymal state concomitant supp 2 nihms910346-supplement-supp_2 supp 3 nihms910346-supplement-supp_3 supp 4 nihms910346-supplement-supp_4 gpx4-wild-type xenograft continued including epithelial-mesenchymal transition high-mesenchymal state cells mesenchymal state-targeting compound mesenchymal gene-expression score mesenchymal state-targeting compounds therapy-resistant cancer cells h358 er-twist1 cells21 therapy-induced neuroendocrine transition specific cell-line exclusions dana-farber cancer institute single-cell rna-seq therapy-resistant cell states ht-1080 fibrosarcoma-derived cells cell-line mesenchymal score selenocysteine-charged transfer rna transforming growth factor-β crispr-cas9-engineered cells monotonic double-sigmoid function cationic lipid-mediated delivery hcc4006 gefitinib-resistant cells24 cell-line mesenchymal scores pmc beta search downstream iron-dependent reactions epithelial cell-state sensitivity ham’s-f12 medium bulk cell-line expression targeted pcr-sanger sequencing li-cor secondary antibodies patient-derived sample mcf-7 er-snail1 mesenchymal state-correlated compounds individual cell-line features yield therapy-resistant cells ctrp auc-similarity matrix11 patient-derived signatures high-mesenchymal state hcc4006 gefitinib-resistant cells druggable lipid-peroxidase pathway
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