
NCBI . NLM . NIH . GOV {
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Title[redir]:
Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration - PMC
Description:
Synaptic loss and neuron death are the underlying cause of neurodegenerative diseases such as Alzheimer
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Keywords {🔍}
mice, gpxbiko, ferroptosis, doi, gpx, neurodegeneration, neurons, cell, lipid, treatment, control, fig, death, hippocampus, pubmed, google, scholar, tam, peroxidation, pmc, vitamin, levels, gpxbikoved, ablation, forebrain, gpxff, tissues, hippocampal, results, brain, compared, free, article, cortex, diet, western, weeks, cognitive, disease, protein, day, impairment, oxidative, cerebral, task, gfap, liproxstatin, blots, alzheimers, degeneration,
Topics {✒️}
ain-93g-modified rodent diet small-molecule ferroptosis inhibitor pmc beta search high-throughput cre reporting detect cre-mediated recombination real-time quantitative pcr post-mortem brain tissue cresyl violet-stained sections renal tubular cells gpx4biko-ved mice treated anti-ferroptosis defense system tam-treated gpx4biko mice tam-treated-gpx4biko mice β-actin loading controls publisher site pdf small-molecule compound average acquisition-trial time iron-dependent form tam-treated control mice morris water maze reactive oxygen species cre-mediated gpx4 ablation vehicle-treated gpx4biko mice small-molecule inhibitors selective neuronal vulnerability cognitively impaired mice cell death induced maze tracking system impaired spatial learning primary antibody overnight 05 versus con-ved cross-bred camk2α-creer important neurodegenerative mechanism real-time qpcr license information pmcid polyunsaturated fatty acids institutional animal care secondary antibody conjugated gpx4biko versus control nissl-stained images normal chow diet apoptotic cell death cell death pathway ferroptotic cell death apoptotic cell death nonapoptotic cell death cell death differ newly characterized form confocal microscopy images biggest risk factor
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