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Keywords {🔍}

doi, pubmed, google, scholar, hippo, yap, cell, pmc, pathway, article, free, signaling, taz, yaptaz, lats, protein, kinase, cells, nuclear, biol, activity, stem, regulation, dev, transcription, complex, transcriptional, cancer, activation, nat, wnt, kinases, module, phosphorylation, figure, regulates, genes, cellular, growth, family, regulate, drosophila, jdevcel, proliferation, mst, target, role, components, cytoplasmic, gene,

Topics {✒️}

β1-integrin/yap/taz signaling axis membrane-anchored metalloproteinase mt1-mmp swi/snf chromatin-remodeling complex stimulate cdc73–β-catenin binding wnt/β-catenin signaling regulates g-protein-coupled receptor signaling salvador/warts/hippo signaling network taz/tead/bmp signaling axis pmc beta search tumour-suppressor genes nf2/merlin yap/taz–tead include bmp4 tubulin cytoskeleton-interacting effector tgf-β–smad pathway mt1-mmp-dependent control ubiquitylation-induced conformational change nuclear β-catenin downregulation increased nuclear β-catenin increased c-myc expression chromatin-remodeling/methyltransferase complexes [75–78] ferm-domain protein expanded sik [salt-inducible kinases jak–stat pathway ligand serum-derived sphingosine-1-phosphate yap-dependent gene transcription cell-type-specific manner wnt/β-catenin signalling β-catenin destruction complex camp/pka signalling reinforces salvador–warts–hippo pathway inhibits taz-driven transformation dissociating phosphoinositide-dependent kinase-1 taz sequester β-catenin nphp transition-zone complex tumor suppressor merlin/nf2 mammalian lats/ndr kinases yap–tead4 combinatorially bind yap–tea domain family plasma membrane-targeting warts homophilic cell–cell contacts activate tead-mediated transcription ww domain-mediated interaction protein–protein interaction network tead–yap complex suppresses β-catenin remains phosphorylated crl4dcaf1-mediated ubiquitylation regulates lineage specification cell fate-controlling integrator apical–basal polarity hypophosphorylated yap/taz translocate perk–eif2α–atf4 axis

Questions {❓}

• Does the Hippo pathway regulate additional effectors besides YAP and TAZ?
• How can the Hippo pathway be therapeutically utilized in regeneration and cancer?
• How do YAP and TAZ differ and how are their nuclear/cytoplasmic functions regulated?
• How does the temporal and spatial organization and regulation of the Hippo pathway occur?
• How is LATS activated in different contexts?
• What underlies the context-dependent physiological roles and activities of YAP and TAZ?

Social Networks {👍}(6)

• https://twitter.com/ncbi
• https://www.facebook.com/ncbi.nlm
• https://www.linkedin.com/company/ncbinlm
• https://twitter.com/nlm_nih
• https://www.facebook.com/nationallibraryofmedicine
• https://www.youtube.com/user/NLMNIH

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• Get to know https://scholar.google.com/scholar_lookup?journal=Dev.%20Cell&title=Kibra%20functions%20as%20a%20tumor%20suppressor%20protein%20that%20regulates%20Hippo%20signaling%20in%20conjunction%20with%20Merlin%20and%20Expanded.&author=J%20Yu&volume=18&publication_year=2010&pages=288-299&pmid=20159598&doi=10.1016/j.devcel.2009.12.012&'s earnings
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• How much revenue does https://doi.org/10.1038/onc.2010.438 bring in?
• See how much https://scholar.google.com/scholar_lookup?journal=Oncogene&title=WW%20domain-mediated%20interaction%20with%20Wbp2%20is%20important%20for%20the%20oncogenic%20property%20of%20TAZ.&author=SW%20Chan&volume=30&publication_year=2011&pages=600-610&pmid=20972459&doi=10.1038/onc.2010.438& makes per month
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• What are the earnings of https://scholar.google.com/scholar_lookup?journal=Cell%20Rep&title=The%20Hippo%20transducer%20TAZ%20interacts%20with%20the%20SWI/SNF%20complex%20to%20regulate%20breast%20epithelial%20lineage%20commitment.&author=A%20Skibinski&volume=6&publication_year=2014&pages=1059-1072&pmid=24613358&doi=10.1016/j.celrep.2014.02.038&?
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• How much does https://scholar.google.com/scholar_lookup?journal=Cell&title=Hippo%20signaling%20regulates%20microprocessor%20and%20links%20cell-density-dependent%20miRNA%20biogenesis%20to%20cancer.&author=M%20Mori&volume=156&publication_year=2014&pages=893-906&pmid=24581491&doi=10.1016/j.cell.2013.12.043& rake in every month?
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• Financial intake of https://doi.org/10.1038/ncb2615
• Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Nat.%20Cell%20Biol&title=YAP%20mediates%20crosstalk%20between%20the%20Hippo%20and%20PI3K%E2%80%93TOR%20pathways%20by%20suppressing%20PTEN%20via%20miR-29.&author=K%20Tumaneng&volume=14&publication_year=2012&pages=1322-1329&pmid=23143395&doi=10.1038/ncb2615&
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• Revenue of https://scholar.google.com/scholar_lookup?journal=Physiol.%20Rev&title=The%20biology%20of%20YAP/TAZ:%20Hippo%20signaling%20and%20beyond.&author=S%20Piccolo&volume=94&publication_year=2014&pages=1287-1312&pmid=25287865&doi=10.1152/physrev.00005.2014&
• Learn how profitable https://doi.org/10.1126/science.1248012 is on a monthly basis
• Check the income stats for https://scholar.google.com/scholar_lookup?journal=Science&title=Stem%20cell%20signaling.%20An%20integral%20program%20for%20tissue%20renewal%20and%20regeneration:%20Wnt%20signaling%20and%20stem%20cell%20control.&author=H%20Clevers&volume=346&publication_year=2014&pages=1248012&pmid=25278615&doi=10.1126/science.1248012&
• What are the total earnings of https://doi.org/10.1038/emboj.2011.487?
• https://scholar.google.com/scholar_lookup?journal=EMBO%20J&title=A%20molecular%20mechanism%20that%20links%20Hippo%20signalling%20to%20the%20inhibition%20of%20Wnt/%CE%B2-catenin%20signalling.&author=M%20Imajo&volume=31&publication_year=2012&pages=1109-1122&pmid=22234184&doi=10.1038/emboj.2011.487&'s financial summary
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• https://doi.org/10.1016/j.devcel.2013.08.013's financial summary
• Earnings of https://scholar.google.com/scholar_lookup?journal=Dev.%20Cell&title=YAP%20and%20TAZ,%20Hippo%20signaling%20targets,%20act%20as%20a%20rheostat%20for%20nuclear%20SHP2%20function.&author=R%20Tsutsumi&volume=26&publication_year=2013&pages=658-665&pmid=24035415&doi=10.1016/j.devcel.2013.08.013&
• How much does https://doi.org/10.1016/j.cell.2006.01.053 earn?
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• Learn how profitable http://dx.doi.org/10.1016/j.celrep.2015.01.007 is on a monthly basis
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• Monthly income for https://doi.org/10.1073/pnas.0605266104
• How much revenue does https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20U.%20S.%20A&title=Glomerulocystic%20kidney%20disease%20in%20mice%20with%20a%20targeted%20inactivation%20of%20Wwtr1.&author=Z%20Hossain&volume=104&publication_year=2007&pages=1631-1636&pmid=17251353&doi=10.1073/pnas.0605266104& produce monthly?
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