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Title[redir]:
CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy - PMC
Description:
Cancer immunotherapy restores and/or enhances effector function of CD8+ T cells in the tumor microenvironment1,2. CD8+ T cells activated by cancer immunotherapy execute tumor clearance mainly by inducing cell death through perforin-granzyme- and ...
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Keywords {๐}
cells, tumor, cell, fig, ifnฮณ, data, slca, hours, extended, ferroptosis, lipid, treated, determined, biological, anova, expression, erastin, mice, relative, replicates, rsl, ros, treatment, human, cancer, oti, mouse, death, doi, cysteinase, google, scholar, pmc, pubmed, stat, primed, article, growth, percentage, viability, control, free, blockade, oneway, aad, antipdl, melanoma, twoway, increased, minutes,
Topics {โ๏ธ}
long-chain-fatty-acid-coa ligase 4 celltiter-glo reagent equal cell-mediated anti-tumor immunity cd45-ova-h2kb+ tumor cells liquid chromatography-mass spectrometry anti-pd-l1 combination therapy fas/fas ligand-pathways3 cell-mediated tumor clearance kaplanโmeier survival curves automated slide-scanning platform id8 tumor-bearing mice specific precursor/product ion pmc beta search plasmid pci-neo-mova nih/nci r01 grants cell-mediated cancer immunity b16 tumor-bearing mice nutrient-deprived cancer cells ova-pulsed wild-type pd-l1 blockade failed 7aad+ id8-ova cells anti-pd-l1 antibody 100 ยตg anti-pd-l1 gsh-glo glutathione assay erastin-induced cell death anti-pd-l1 therapy 1x gsh-gloโข reagent rsl3-induced cell death cell-promoted tumor ferroptosis cd45-h2kb-ova+ cells ova-pulsed b16 cells 7aad+ b16-ova cells inase-induced cell death human pre-gapdh reverse 7-aad+ b16-ova cells anti-ova257โ264-h2kb antibodies rsl3-induced lipid ros hrp-conjugated secondary antibodies human pre-gapdh forward pathogen-free conditions induce cell lysis human pre-slc7a11 reverse inverse-normal signature scores cystine-free medium [google scholar] 15 7-aad+ stat1 wild-type nih/nci grant kaplan-meier methods human pre-slc7a11 forward 14c-cystine supplemented medium
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