
NCBI . NLM . NIH . GOV {
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Title[redir]:
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis - PMC
Description:
Ferroptosis is a regulated form of cell death induced by loss of glutathione peroxidase 4 (GPX4) phospholipid peroxidase activity and lethal accumulation of reactive oxygen species. Small-molecule inhibitors of GPX4 induce ferroptosis; however, the ...
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Keywords {🔍}
doi, cell, gpx, cells, ferroptosis, fig, protein, pubmed, google, scholar, lipid, death, erastin, rrsl, inhibition, free, pmc, article, phkg, alox, rrslfcn, expression, binding, treatment, activity, analysis, pufas, site, lipoxygenase, gfpgpx, rsl, antibody, lipoxygenases, iron, oxidation, cellular, treated, sec, inhibitors, role, assay, western, lines, gsh, genes, culture, fatty, biol, peroxidation, species,
Topics {✒️}
oncogenic-ras-harboring cancer cells n-terminal “beta-barrel” domain rhabdomyolysis-induced renal failure gfp-gpx4–expressing ht-1080 cells comprehensive lc-ms/ms analysis anti–fcn-conjugated sepharose beads n-terminal gfp fusion genotype-selective antitumor agents period2-dependent growth arrest bj-derived cell lines iron-dependent cell death org/lookup/suppl/doi u-2-os cell line pmc beta search stably expressing clones university medicine berlin–charit� aif-mediated cell death cells stably expressing bax/bak double knockout bis-allylic position retards lysophosphatidylcholine-induced cellular injury lc-ms peak corresponds anti-gfp antibody revealed erastin-induced cell death expressed gfp-tagged alox5 unlike erastin-induced translocation lc-ms/ms conditions express mutant ras polyunsaturated fatty acids maturation-dependent vulnerability small-molecule–based inhibition gfp-gpx4 fusion protein cell growth-related variations shrna suppressor screen d-pufa uptake resulted gfp-a46c protein band infected u-2-os cells lc-ms/ms analysis formate-hydrogen-lyase-linked pbabe-puro vector gfp-gpx4 protein band ferroptosis-sensitive cell lines microsomal-type arachidonate 12-lipoxygenase phkg2-dependent iron pool cystine-glutamate antiporter ms–based gpx4 assay anti-gpx4 antibody protein d-lin prevented generation cellular gfp-gpx4 proteins vitro-purified gpx4u46c protein
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